Proteins & Peptides

14-3-3 beta

NEW
YWHAB, also known as 14-3-3 protein beta/alpha, is 14-3-3 family plays a key regulatory role in signal transduction, checkpoint control, apoptotic and nutrient-sensing pathways. 14-3-3 proteins are highly conserved and ubiquitously expressed. There are at least seven isoforms, beta, gamma, epsilon, sigma, zeta, tau and eta that have been identified in mammals. The 14-3-3 beta, a subtype of the 14-3-3 proteins, was found in B Cells, brain and liver etc. This 14-3-3 beta has been shown to interact with RAF1 and CDC25 phosphatases, suggesting that it may play a role in linking mitogenic signaling and the cell cycle machinery. Recombinant human YWHAB, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.

Article No

PAT-8FC347

Application

Electrophoresis

Species Reactivity

human

Size

50ug

Source / Host

bacteria

Specifications

MW 30.6 kDa (270aa) confirmed by MALDI-TOF
NCBI Number NP_003395
Application Electrophoresis
Article No PAT-8FC347
BioSite Brand BioSite
Concentration 1 mg/ml (determined by Absorbance at 280nm)
Description YWHAB, also known as 14-3-3 protein beta/alpha, is 14-3-3 family plays a key regulatory role in signal transduction, checkpoint control, apoptotic and nutrient-sensing pathways. 14-3-3 proteins are highly conserved and ubiquitously expressed. There are at least seven isoforms, beta, gamma, epsilon, sigma, zeta, tau and eta that have been identified in mammals. The 14-3-3 beta, a subtype of the 14-3-3 proteins, was found in B Cells, brain and liver etc. This 14-3-3 beta has been shown to interact with RAF1 and CDC25 phosphatases, suggesting that it may play a role in linking mitogenic signaling and the cell cycle machinery. Recombinant human YWHAB, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Supplier BioSite
Domain 1-246aa
Keywords Signal Transduction,Apoptosis
Notes YWHAB, also known as 14-3-3 protein beta/alpha, is 14-3-3 family plays a key regulatory role in signal transduction, checkpoint control, apoptotic and nutrient-sensing pathways. 14-3-3 proteins are highly conserved and ubiquitously expressed. There are at least seven isoforms, beta, gamma, epsilon, sigma, zeta, tau and eta that have been identified in mammals. The 14-3-3 beta, a subtype of the 14-3-3 proteins, was found in B Cells, brain and liver etc. This 14-3-3 beta has been shown to interact with RAF1 and CDC25 phosphatases, suggesting that it may play a role in linking mitogenic signaling and the cell cycle machinery. Recombinant human YWHAB, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
Alias Names 14-3-3 protein beta/alpha, GW128, HEL-S-1, HS1, KCIP-1, YWHAA
Product Type Proteins & Peptides
Purity > 90% by SDS-PAGE
Research Area Cell Signaling, Cell Death
Sequence MGSSHHHHHH SSGLVPRGSH MGSHMTMDKS ELVQKAKLAE QAERYDDMAA AMKAVTEQGH ELSNEERNLL SVAYKNVVGA RRSSWRVISS IEQKTERNEK KQQMGKEYRE KIEAELQDIC NDVLELLDKY LIPNATQPES KVFYLKMKGD YFRYLSEVAS GDNKQTTVSN SQQAYQEAFE ISKKEMQPTH PIRLGLALNF SVFYYEILNS PEKACSLAKT AFDEAIAELD TLNEESYKDS TLIMQLLRDN LTLWTSENQG DEGDAGEGEN
Size 50ug
Source / Host bacteria
Species Reactivity human
Storage Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Substrate / Buffer Liquid. In Phosphate Buffered Saline (pH7.4) containing 10% glycerol
UniProt Number P31946
Product Page Updated 2019-04-15T12:57:56.440Z

Shipping info

The delivery time for this item is approximately 7-9 business days. If other deviations occur, this will be noted on the order confirmation or communicated via email. Please note, we do reserve the right to select the best packaging and shipping method in order to insure the stability of the product and allow efficient order tracking.