14-3-3 beta

Article No PAT-8FC347
Product Type Proteins & Peptides
Research Area Cell Signaling
Application Electrophoresis
Size 50ug

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Specifications

MW 30.6 kDa (270aa) confirmed by MALDI-TOF
NCBI Number NP_003395
Country Availability SE, NO, DK, FI
BioSite Brand BioSite
Concentration 1 mg/ml (determined by Absorbance at 280nm)
Description YWHAB, also known as 14-3-3 protein beta/alpha, is 14-3-3 family plays a key regulatory role in signal transduction, checkpoint control, apoptotic and nutrient-sensing pathways. 14-3-3 proteins are highly conserved and ubiquitously expressed. There are at least seven isoforms, beta, gamma, epsilon, sigma, zeta, tau and eta that have been identified in mammals. The 14-3-3 beta, a subtype of the 14-3-3 proteins, was found in B Cells, brain and liver etc. This 14-3-3 beta has been shown to interact with RAF1 and CDC25 phosphatases, suggesting that it may play a role in linking mitogenic signaling and the cell cycle machinery. Recombinant human YWHAB, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Supplier BioSite
Keywords Signal Transduction,Apoptosis
Notes YWHAB, also known as 14-3-3 protein beta/alpha, is 14-3-3 family plays a key regulatory role in signal transduction, checkpoint control, apoptotic and nutrient-sensing pathways. 14-3-3 proteins are highly conserved and ubiquitously expressed. There are at least seven isoforms, beta, gamma, epsilon, sigma, zeta, tau and eta that have been identified in mammals. The 14-3-3 beta, a subtype of the 14-3-3 proteins, was found in B Cells, brain and liver etc. This 14-3-3 beta has been shown to interact with RAF1 and CDC25 phosphatases, suggesting that it may play a role in linking mitogenic signaling and the cell cycle machinery. Recombinant human YWHAB, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
Alias Names 14-3-3 protein beta/alpha, GW128, HEL-S-1, HS1, KCIP-1, YWHAA
Purity > 90% by SDS-PAGE
Sequence MGSSHHHHHH SSGLVPRGSH MGSHMTMDKS ELVQKAKLAE QAERYDDMAA AMKAVTEQGH ELSNEERNLL SVAYKNVVGA RRSSWRVISS IEQKTERNEK KQQMGKEYRE KIEAELQDIC NDVLELLDKY LIPNATQPES KVFYLKMKGD YFRYLSEVAS GDNKQTTVSN SQQAYQEAFE ISKKEMQPTH PIRLGLALNF SVFYYEILNS PEKACSLAKT AFDEAIAELD TLNEESYKDS TLIMQLLRDN LTLWTSENQG DEGDAGEGEN
Source / Host bacteria
Species Reactivity human
Storage Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Substrate / Buffer Liquid. In Phosphate Buffered Saline (pH7.4) containing 10% glycerol
UniProt Number P31946
Product Page Updated 2019-04-15T12:57:56.440Z

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Source/Host:

bacteria

Species reactivity:

human human