14-3-3 beta

Article No PAT-80001-2
Product Type Proteins & Peptides
Research Area Cell Signaling
Application Electrophoresis
Size 0.5mg

Specifications

MW 28 kDa (246 aa), confirmed by MALDI-TOF.
NCBI Number NP_003395
Country Availability all
BioSite Brand BioSite
Concentration 1 mg/ml (determined by Bradford assay)
Description 14-3-3 beta, 1-246aa, Human, E.coli
Supplier BioSite
Notes The 14-3-3 family plays a key regulatory role in signal transduction, checkpoint control, apoptotic and nutrient-sensing pathways. 14-3-3 proteins are highly conserved and ubiquitously expressed. There are at least seven isoforms, beta, gamma, epsilon,sigma, zeta, tau and eta that have been identified in mammals. The 14-3-3 beta, a subtype of the 14-3-3 proteins, was found in B Cells, brain and liver etc. This 14-3-3 beta has been shown to interact with RAF1 and CDC25 phosphatases, suggesting that it may play a role in linking mitogenic signaling and the cell cycle machinery. Recombinant human 14-3-3 beta was expressed in E.coli and purified by using conventional chromatography techniques.
Alias Names Tyrosine 3-monocxygenase/tryptopan 5-monooxygenase activation protein beta polypeptide, Tyrosine 3-monocxygenase/tryptopan 5-monooxygenase activation protein, beta polypeptide, 14-3-3 beta, YWHAB, GW128, HS1, KCIP-1, Tyrosine 3-monocxygenase/tryptopan 5-monooxygenase activation protein, beta polypeptide 14 3 3 protein beta/alpha, Brain protein 14 3 3 beta isoform, GW 128, HS 1, KCIP 1, KCIP1, Protein 1054, Protein kinase C inhibitor protein 1, Tyrosine 3 Monooxygenase/Tryptophan 5 Monooxygenase Activation Protein Beta Polypeptide.
Purity > 90% by SDS - PAGE
Sequence MTMDKSELVQ KAKLAEQAER YDDMAAAMKA VTEQGHELSN EERNLLSVAY KNVVGARRSS WRVISSIEQK TERNEKKQQM GKEYREKIEA ELQDICNDVL ELLDKYLIPN ATQPESKVFY LKMKGDYFRY LSEVASGDNK QTTVSNSQQA YQEAFEISKK EMQPTHPIRL GLALNFSVFY YEILNSPEKA CSLAKTAFDE AIAELDTLNE ESYKDSTLIM QLLRDNLTLW TSENQGDEGD AGEGEN
Source / Host bacteria
Species Reactivity human
Storage Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
Substrate / Buffer Liquid in 20mM Tris pH 8.0, 1mM EDTA, 50mM NaCl
Product Page Updated 2018-10-30T15:53:36.445Z

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Source/Host:

bacteria

Species reactivity:

human human