Article No
P019-100MG
CAS No | 28822-58-4 |
MW | 222.24 |
Article No | P019-100MG |
Country Availability | SE, FI, DK, NO, IS, EE, LV, LT |
Components | Inhibitor / activator |
Description | IBMX |
Supplier | Arbor Assays |
Notes | IBMX is a widely-used non-specific inhibitor of cyclic AMP and cyclic GMP phosphodiesterases (PDEs) with IC50s from 7 to 50 µM for PDE1-5, PDE7, and PDE11. PDE8A, PDE8B, and PDE9 are insensitive to IBMX. By inhibiting PDEs, IBMX increases cellular cAMP and cGMP levels, activating cyclic-nucleotide-regulated protein kinases. Methylxanthines, including IBMX, caffeine, and theophylline, bind adenosine receptors, typically antagonizing the suppressive effects of natural agonists. Suppresses alpha-adrenoceptor-mediated 5-HT release from neuroendocrine epithelial cells (IC50 = 1.3 µM). |
Alias Names | 3,7-Dihydro-1-methyl-3-(2-methylpropyl)-1H-purine-2,6-dione, NSC 165960, 1-Methyl-3-Isobutylxanthine, Isobutylmethylxanthine |
Product Type | Chemicals & Biochemicals |
Protocol | Soluble to 15 mg/mL in DMF or DMSO. |
Shipping Information | BLUE ICE |
Size | 100MG |
Species Reactivity | synthetic |
Storage | RT |
Technical Specifications | FORMULA: C10H14N4O2 CAS NUMBER: 28822-58-4 |
Product Page Updated | 2024-03-04T10:32:24.675Z |