Article No
MON9046
Mouse anti-MVP/LRP, clone 1032
Mouse anti-MVP/LRP, clone 1032
Antibodies Primary
Specifications
| Additional Information | 1032 Is specific for the major vault protein, a 104-kDa highly conserved protein interacting with estrogen receptor. It is one of a series of four mAbs which recognize different epitopes of the protein. Major vault proteins have a complex morphology, including several small molecules of RNA, but a single protein species. The MVP accounts for >70% of their mass. Their shape is reminiscent of the nucleopore central plug. Treatment of cells with estradiol increases the amount of MVP in nuclear extract. The hormone-dependent interaction of vaults with ER is prevented in vitro by sodium molybdate. Antibodies to estrogen, progesterone and glucocorticoid receptors are able to co-immunoprecipitate the MVP. MVP is overexpressed in many neoplastic tissues and cell lines. Expression of MVP predicts a poor response to chemotherapy. |
| Application | IF, IP, WB |
| Article No | MON9046 |
| Country Availability | SE, FI, DK, NO, IS, EE, LV, LT |
| Clone | 1032 |
| Clone Type | monoclonal |
| Concentration | 100 ug/ml |
| Conjugation | Unconjugated |
| Description | Mouse anti-MVP/LRP, clone 1032 |
| Supplier | SANBIO bv/Monosan |
| Format | - |
| Immunogen | affinity purified nuclear extract proteins |
| Isotype | IgM |
| Notes | 1032 Is specific for the major vault protein, a 104-kDa highly conserved protein interacting with estrogen receptor. It is one of a series of four mAbs which recognize different epitopes of the protein. Major vault proteins have a complex morphology, including several small molecules of RNA, but a single protein species. The MVP accounts for >70% of their mass. Their shape is reminiscent of the nucleopore central plug. Treatment of cells with estradiol increases the amount of MVP in nuclear extract. The hormone-dependent interaction of vaults with ER is prevented in vitro by sodium molybdate. Antibodies to estrogen, progesterone and glucocorticoid receptors are able to co-immunoprecipitate the MVP. MVP is overexpressed in many neoplastic tissues and cell lines. Expression of MVP predicts a poor response to chemotherapy. |
| Product Type | Antibodies Primary |
| Protocol | IHC-fr, IHC-P, IF, IP, WB |
| Shipping Information | blue ice |
| Size | 100 ug |
| Source / Host | mouse |
| Species Reactivity | human |
| Storage | 2-8°C |
| Substrate / Buffer | PBS with 0.02% sodium azide |
| Product Page Updated | 2024-01-12T18:37:31.725Z |
