Article No
MON3058
Mouse anti-Desmoglein-3, clone 5G11
Mouse anti-Desmoglein-3, clone 5G11
Antibodies Primary
Specifications
| Additional Information | Desmoglein 3 is a member of the desmosomal cadherin family that comprise the desmogleins and desmocollins. Desmosomes are cell-cell junctions in most epithelial cells and serve to link the intermediate filament cytoskeletons of adjacent cells. Within the desmosome the extracellular domain of desmoglein is essential for calcium dependent heterophilic binding to the desmocollins, whereas the intracellular domain is essential for binding to the desmosomal plaque protein, plakoglobin. Desmoglein 3 is synthesized in both the basal and the lower suprabasal compartments. The monoclonal antibody 5G11 reacts with the 140 kDa desmoglein 3 protein. Furthermore it is not cross reactive with desmoglein 1 or desmoglein 2. |
| Application | IF, IP, WB |
| Article No | MON3058 |
| Country Availability | SE, FI, DK, NO, IS, EE, LV, LT |
| Clone | 5G11 |
| Clone Type | monoclonal |
| Concentration | 100 ug/ ml |
| Conjugation | Unconjugated |
| Description | Mouse anti-Desmoglein-3, clone 5G11 |
| Supplier | SANBIO bv/Monosan |
| Format | - |
| Immunogen | Unknown or proprietery to MONOSAN and/or its suppliers |
| Isotype | IgG1 |
| Notes | Desmoglein 3 is a member of the desmosomal cadherin family that comprise the desmogleins and desmocollins. Desmosomes are cell-cell junctions in most epithelial cells and serve to link the intermediate filament cytoskeletons of adjacent cells. Within the desmosome the extracellular domain of desmoglein is essential for calcium dependent heterophilic binding to the desmocollins, whereas the intracellular domain is essential for binding to the desmosomal plaque protein, plakoglobin. Desmoglein 3 is synthesized in both the basal and the lower suprabasal compartments. The monoclonal antibody 5G11 reacts with the 140 kDa desmoglein 3 protein. Furthermore it is not cross reactive with desmoglein 1 or desmoglein 2. |
| Product Type | Antibodies Primary |
| Protocol | IF,IP,IHC-P,WB |
| Shipping Information | blue ice |
| Size | 1 ml |
| Source / Host | mouse |
| Species Reactivity | human |
| Storage | 2-8°C |
| Substrate / Buffer | PBS with 0.1% BSA and 0.02% sodium azide |
| Product Page Updated | 2024-01-12T18:37:31.725Z |
