Article No
MK-15-3
Application | IHC, IP, WB |
Article No | MK-15-3 |
Country Availability | SE, FI, DK, NO, IS, EE, LV, LT, FO, GL |
Clone | 3H9 |
Clone Type | monoclonal |
Concentration | 1 mg/mL |
Conjugation | Unconjugated |
Description | Anti-Rb (Human) mAb |
Supplier | MBL |
Immunogen | Recombinant human Rb (612-928 a.a.) |
Isotype | IgG2a k |
Notes | Mutation of the retinoblastoma tumor suppressor gene alone is sufficient to cause retinoblastoma in humans, suggesting that it might play a role in the normal coordination of cell proliferation and cell death. Deletion or mutational inactivation of the retinoblastoma tumor suppressor protein (Rb) is correlated with the genesis of a variety of human cancers including retinoblastoma, osteosarcoma, and carcinomas of the breast, bladder, and lung. Rb protein is phosphorylated by cyclinD-Cdk4/Cdk6 and cyclinA/cyclinE-Cdk2 during the G1/S transition. This phosphorylation causes the inactivation of the growth inhibitory functions of Rb. Rb undergoes phosphorylation and functional inactivation, permitting the cell to proceed into late G1. |
Product Type | Antibodies Primary |
Shipping Information | 4°C |
Size | 100 µg |
Source / Host | mouse |
Species Reactivity | human |
Stability | 1 year |
Storage | -20°C |
Substrate / Buffer | 100 μg IgG in 100 μl PBS containing 50% glycerol, pH 7.2. Contains no preservatives. |
Technical Specifications | Mutation of the retinoblastoma tumor suppressor gene alone is sufficient to cause retinoblastoma in humans, suggesting that it might play a role in the normal coordination of cell proliferation and cell death. Deletion or mutational inactivation of the retinoblastoma tumor suppressor protein (Rb) is correlated with the genesis of a variety of human cancers including retinoblastoma, osteosarcoma, and carcinomas of the breast, bladder, and lung. Rb protein is phosphorylated by cyclinD-Cdk4/Cdk6 and cyclinA/cyclinE-Cdk2 during the G1/S transition. This phosphorylation causes the inactivation of the growth inhibitory functions of Rb. Rb undergoes phosphorylation and functional inactivation, permitting the cell to proceed into late G1. |
Product Page Updated | 2023-12-29T16:20:16.638Z |