Article No
M186-7
Application | WB |
Article No | M186-7 |
Country Availability | SE, FI, DK, NO, IS, EE, LV, LT, FO, GL |
Clone | 8E10 |
Clone Type | monoclonal |
Conjugation | HRP |
Description | Anti-LC3 mAb-HRP-DirecT |
Supplier | MBL |
Immunogen | Human LC3 (MAP1LC3B), 1-120 aa (recombinant) |
Isotype | IgG2a k |
Notes | Macroautophagy mediates the bulk degradation of cytoplasmic components. These components are delivered to lysosomes via autophagosomes. The microtubule-associated protein 1 light chain 3 (LC3), a homologue of yeast Atg8 (Aut7/Apg8), localizes to autophagosomal membranes after post-translational modifications. The C-terminal fragment of LC3 is cleaved immediately following synthesis to yield a cytosolic form called LC3-I (18 kDa). A subpopulation of LC3-I is further converted to an autophagosome-associating form, LC3-II (16 kDa). This antibody can detect both forms of LC3. |
Product Type | Antibodies Primary |
Research Area | Cell Death |
Shipping Information | 4°C |
Size | 50 µl |
Source / Host | mouse |
Species Reactivity | human, mouse, rat, hamster |
Storage | 4°C |
Substrate / Buffer | PBS/Preservative/Stabilizer |
Technical Specifications | Macroautophagy mediates the bulk degradation of cytoplasmic components. These components are delivered to lysosomes via autophagosomes. The microtubule-associated protein 1 light chain 3 (LC3), a homologue of yeast Atg8 (Aut7/Apg8), localizes to autophagosomal membranes after post-translational modifications. The C-terminal fragment of LC3 is cleaved immediately following synthesis to yield a cytosolic form called LC3-I (18 kDa). A subpopulation of LC3-I is further converted to an autophagosome-associating form, LC3-II (16 kDa). This antibody can detect both forms of LC3. |
Product Page Updated | 2023-12-29T16:20:16.638Z |