Article No
M143-3
Anti-GFRα1 (Human) mAb
Anti-GFRα1 (Human) mAb
Antibodies Primary
Specifications
| Application | FC, IP |
| Article No | M143-3 |
| Country Availability | SE, FI, DK, NO, IS, EE, LV, LT, FO, GL |
| Clone | 3H8 |
| Clone Type | monoclonal |
| Concentration | 1 mg/mL |
| Conjugation | Unconjugated |
| Description | Anti-GFRα1 (Human) mAb |
| Supplier | MBL |
| Immunogen | Extracellular domain Recombinant human GFRα1 (24-440 aa) |
| Isotype | IgG2b |
| Notes | Glial cell line-derived neurotrophic factor (GDNF) family plays a critical role in neurodevelopment and survival of central and peripheral neurons. The biological activity of GDNF family through receptor protein tyrosine kinase Ret and require a ligand specific co-receptor α (GFRα1, binds GDNF, whereas GFRα2 binds NRTN, GFRα3 binds ARTN and GFRα4 binds PSPN). Human GFRα1 is constituted from 465 amino acids and attach to the cell membrane by glycosylphosphatidylinositol (GPI) anchoring manner. It is widely accepted that homodimeric GDNF induce the complex formation of GFRα1 and further the stoichiometry of the signaling complex with GDNF2-GFRα12-Ret2, but the mechanism of complex formation remain unclear. |
| Product Type | Antibodies Primary |
| Shipping Information | 4°C |
| Size | 100 µg |
| Source / Host | mouse |
| Species Reactivity | human |
| Stability | 1 year |
| Storage | -20°C |
| Substrate / Buffer | 100 μg IgG in 100 μl volume of PBS containing 50% glycerol, pH 7.2. No preservative is contained. |
| Technical Specifications | Glial cell line-derived neurotrophic factor (GDNF) family plays a critical role in neurodevelopment and survival of central and peripheral neurons. The biological activity of GDNF family through receptor protein tyrosine kinase Ret and require a ligand specific co-receptor α (GFRα1, binds GDNF, whereas GFRα2 binds NRTN, GFRα3 binds ARTN and GFRα4 binds PSPN). Human GFRα1 is constituted from 465 amino acids and attach to the cell membrane by glycosylphosphatidylinositol (GPI) anchoring manner. It is widely accepted that homodimeric GDNF induce the complex formation of GFRα1 and further the stoichiometry of the signaling complex with GDNF2-GFRα12-Ret2, but the mechanism of complex formation remain unclear. |
| Product Page Updated | 2023-12-29T16:20:16.638Z |
