Article No
M109-3
Application | FC, IP, WB |
Article No | M109-3 |
Country Availability | SE, FI, DK, NO, IS, EE, LV, LT, FO, GL |
Clone | 1-55-4 |
Clone Type | monoclonal |
Concentration | 1 mg/mL |
Conjugation | Unconjugated |
Description | Anti-CD61 (gpIIIa) (Mouse) mAb |
Supplier | MBL |
Immunogen | Mouse platelet |
Isotype | IgG2a k |
Notes | Platelet activation results in a conformational change of the membrane spanning platelet integrin GPIIb/IIIa (αIIbβ3, CD41/CD61) enabling the binding of the plasma protein fibrinogen. This binding is primarily reversible, but it enhances platelet activation by outside-in signal causing receptor clustering, platelet secretion, and finally irreversible fibrinogen binding and platelet aggregation. |
Product Type | Antibodies Primary |
Shipping Information | 4°C |
Size | 100 µg |
Source / Host | rat |
Species Reactivity | mouse |
Stability | 1 year |
Storage | -20°C |
Substrate / Buffer | 100 μg IgG in 100 μl volume of PBS containing 50% glycerol, pH 7.2. No preservative is contained. |
Technical Specifications | Platelet activation results in a conformational change of the membrane spanning platelet integrin GPIIb/IIIa (αIIbβ3, CD41/CD61) enabling the binding of the plasma protein fibrinogen. This binding is primarily reversible, but it enhances platelet activation by outside-in signal causing receptor clustering, platelet secretion, and finally irreversible fibrinogen binding and platelet aggregation. |
Product Page Updated | 2023-12-29T16:20:16.638Z |