Article No
M045-3
Anti-Phospho-RB (Ser780) (Human) mAb
Anti-Phospho-RB (Ser780) (Human) mAb
Antibodies Primary
Specifications
| Application | WB |
| Article No | M045-3 |
| Country Availability | SE, FI, DK, NO, IS, EE, LV, LT, FO, GL |
| Clone | 2C4 |
| Clone Type | monoclonal |
| Concentration | 1 mg/mL |
| Conjugation | Unconjugated |
| Description | Anti-Phospho-RB (Ser780) (Human) mAb |
| Supplier | MBL |
| Immunogen | synthetic human phospho-RB (Ser780) peptide, TRPPTLS (PO3) PIPHIP, which corresponding to amino acids 774-786 of human pR |
| Isotype | IgG1 |
| Notes | Cyclin-dependent kinases (Cdks) play important roles in the regulation of the cell cycle. RB protein (pRB) is phosphorylated by cyclin D-Cdk4/Cdk6 and cyclin A/cyclin E-Cdk2 during the G1/S transition. This phosphorylation causes the inactivation of the growth inhibitory functions of pRB. pRB undergo phosphorylationm and attendant functional inactivation, the cell proceed into late G1. Cyclin D-Cdk4 specifically phosphorylates Ser780 in pRB, while cyclin E-Cdk2 and cyclin A-Cdk2 does not. |
| Product Type | Antibodies Primary |
| Shipping Information | 4°C |
| Size | 100 µg |
| Source / Host | mouse |
| Species Reactivity | human |
| Stability | 1 year |
| Storage | -20°C |
| Substrate / Buffer | 100 μg IgG in 100 μl volume of PBS containing 50% glycerol, pH 7.2. No preservative is contained. |
| Technical Specifications | Cyclin-dependent kinases (Cdks) play important roles in the regulation of the cell cycle. RB protein (pRB) is phosphorylated by cyclin D-Cdk4/Cdk6 and cyclin A/cyclin E-Cdk2 during the G1/S transition. This phosphorylation causes the inactivation of the growth inhibitory functions of pRB. pRB undergo phosphorylationm and attendant functional inactivation, the cell proceed into late G1. Cyclin D-Cdk4 specifically phosphorylates Ser780 in pRB, while cyclin E-Cdk2 and cyclin A-Cdk2 does not. |
| Product Page Updated | 2023-12-29T16:20:16.638Z |
