Article No
LS-C58283-0.1
CYCS / Cytochrome c
Cytochrome c antibody LS-C58283 is an unconjugated mouse monoclonal antibody to human Cytochrome c (CYCS). Validated for ELISA and Flow.
Antibodies Primary
Specifications
| NCBI Number | 54205 |
| Application | ELISA, FC |
| Article No | LS-C58283-0.1 |
| Country Availability | SE, FI, DK, NO, FO, GL |
| Clone | 2G8 |
| Clone Type | monoclonal |
| Concentration | 1 mg/ml |
| Conjugation | Unconjugated |
| Description | Cytochrome c antibody LS-C58283 is an unconjugated mouse monoclonal antibody to human Cytochrome c (CYCS). Validated for ELISA and Flow. |
| Supplier | LifeSpan Biosciences |
| Entrez Gene ID | 54205 |
| Gene Symbol | CYCS |
| Immunogen | Human cytochrome C |
| Isotype | IgG1 |
| Notes | Cytochrome c antibody LS-C58283 is an unconjugated mouse monoclonal antibody to human Cytochrome c (CYCS). Validated for ELISA and Flow. |
| Alias Names | CYCS, CYC, HCS, THC4, Cytochrome c, Cytochrome c, somatic |
| Product Type | Antibodies Primary |
| Protocol | Flow Cytometry: Use 10 ul of the suggested working dilution to label 1x10^6 cells in 100 ul. Method sheets are available on request. |
| Purification | Affinity Purified |
| Shipping Information | RT |
| Size | 0.1 mg |
| Source / Host | mouse |
| Species Reactivity | human |
| Storage | -20°C |
| Substrate / Buffer | PBS, 0.09% Sodium Azide |
| Technical Specifications | Recognizes cytochrome c, originally termed Apaf-2, an evolutionarily conserved protein which acts as an essential mitochondrial electron carrier between respirable substrates and oxygen, during aerobic energy production. A second major function for cytochrome c is its role as an intermediate in apoptosis, both through its association with inositol-3-phosphate receptor (IP3 receptor) which acts as an ER calcium release channel, and its association with apoptotic protease activating factor 1 (Apaf-1), resulting in the formation of the apoptosome protein complex which then recruits and activates pro-caspase 9 (Apaf-3). Clone 2G8 is reported to block the role of cytochrome c as a co-factor in the activation of caspase 9. Removal of sodium azide is recommended prior to use in functional assays. |
| Product Page Updated | 2024-04-12T09:51:03.289Z |
