Article No
LS-C498439-50
BHLHB2 / DEC1
DEC1 antibody LS-C498439 is an FITC-conjugated rabbit polyclonal antibody to human DEC1 (BHLHB2). Validated for ELISA.
Antibodies Primary
Specifications
| NCBI Number | 8553 |
| Application | ELISA |
| Article No | LS-C498439-50 |
| Country Availability | SE, FI, DK, NO, FO, GL |
| Clone | 1.60E+10 |
| Clone Type | polyclonal |
| Concentration | 1 mg/ml |
| Conjugation | FITC |
| Description | DEC1 antibody LS-C498439 is an FITC-conjugated rabbit polyclonal antibody to human DEC1 (BHLHB2). Validated for ELISA. |
| Supplier | LifeSpan Biosciences |
| Entrez Gene ID | 8553 |
| Gene Symbol | BHLHE40 |
| Immunogen | Recombinant human Class E basic helix-loop-helix protein 40 protein (184-302AA) |
| Isotype | IgG |
| Notes | DEC1 antibody LS-C498439 is an FITC-conjugated rabbit polyclonal antibody to human DEC1 (BHLHB2). Validated for ELISA. |
| Alias Names | BHLHE40, BHLHB2, HLHB2, SHARP2, Stra14, SHARP-2 |
| Product Type | Antibodies Primary |
| Protocol | ELISA |
| Purification | Protein G Purified |
| Shipping Information | RT |
| Size | 50 µg |
| Source / Host | rabbit |
| Species Reactivity | human |
| Storage | -20°C, -80°C |
| Substrate / Buffer | PBS, pH 7.4, 0.03% Proclin 300, 50% glycerol. |
| Technical Specifications | Transcriptional repressor involved in the regulation of the circadian rhythm by negatively regulating the activity of the clock genes and clock-controlled genes. Acts as the negative limb of a novel autoregulatory feedback loop (DEC loop) which differs from the one formed by the PER and CRY transcriptional repressors (PER/CRY loop). Both these loops are interlocked as it represses the expression of PER1/2 and in turn is repressed by PER1/2 and CRY1/2. Represses the activity of the circadian transcriptional activator: CLOCK-ARNTL/BMAL1|ARNTL2/BMAL2 heterodimer by competing for the binding to E-box elements (5'-CACGTG-3') found within the promoters of its target genes. Negatively regulates its own expression and the expression of DBP and BHLHE41/DEC2. Acts as a corepressor of RXR and the RXR-LXR heterodimers and represses the ligand-induced RXRA and NR1H3/LXRA transactivation activity. May be involved in the regulation of chondrocyte differentiation via the cAMP pathway. |
| Product Page Updated | 2024-04-12T09:51:03.289Z |
