Article No
LS-C44994-0.1
Complement C8
Complement C8 antibody LS-C44994 is an unconjugated mouse monoclonal antibody to human Complement C8. Validated for ELISA, Flow, IHC and WB.
Antibodies Primary
Specifications
| Application | ELISA, FC, IHC, WB |
| Article No | LS-C44994-0.1 |
| Country Availability | SE, FI, DK, NO, FO, GL |
| Clone | 056B-373 |
| Clone Type | monoclonal |
| Concentration | 1.08 mg/ml |
| Conjugation | Unconjugated |
| Description | Complement C8 antibody LS-C44994 is an unconjugated mouse monoclonal antibody to human Complement C8. Validated for ELISA, Flow, IHC and WB. |
| Supplier | LifeSpan Biosciences |
| Immunogen | Purified human C8. |
| Isotype | IgG1 |
| Notes | Complement C8 antibody LS-C44994 is an unconjugated mouse monoclonal antibody to human Complement C8. Validated for ELISA, Flow, IHC and WB. |
| Product Type | Antibodies Primary |
| Purification | Protein A Purified |
| Shipping Information | RT |
| Size | 0.1 mg |
| Source / Host | mouse |
| Species Reactivity | human |
| Storage | -20°C |
| Substrate / Buffer | BBS, 0.1% Sodium Azide |
| Technical Specifications | Recognizes complement component 8 (C8), a 151 kD member of the complement C6/C7/C8/C9 family, present in blood serum. C8 is a terminal component of the complement system, part of both the complement membrane attack complex (MAC), and important to MAC assembly. C8 binds to the C5b-7 complex, anchored to the membrane, creating C5b-8. C5b-8 binds C9 and catalyses the polymerization of C9 molecules to form C5-b9 (MAC). C8 is thought to contain lipid binding sites, facilitating the insertion of MAC into the membrane. Defects in the alpha chain of C8 can result in complement C8 deficiency type I. Furthermore, C8 deficiencies can cause recurring bacterial infections, in particular from Neisseria meningitides. |
| Product Page Updated | 2024-04-12T09:51:03.289Z |
