WT1 / Wilms Tumor 1

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WT1 / Wilms Tumor 1 Antibody (aa1-181, clone 6F-H2, Ready-to-Use) LS-C391128

Article No

LS-C391128-7

Application

FC, IF, IHC, IHC

Species Reactivity

human

Size

7 ml

Clone

6F-H2

Source / Host

mouse

Specifications

NCBI Number 7490
Application FC, IF, IHC, IHC
Article No LS-C391128-7
Clone 6F-H2
Clone Type monoclonal
Concentration 1 mg/ml
Conjugation Unconjugated
Description WT1 / Wilms Tumor 1 Antibody (aa1-181, clone 6F-H2, Ready-to-Use) LS-C391128
Supplier LifeSpan Biosciences Inc
Immunogen Recombinant protein corresponding to residues 1-181 from the human protein.
Isotype IgG1 k
Notes Wilms Tumor 1 antibody LS-C391128 is an unconjugated mouse monoclonal antibody to human Wilms Tumor 1 (WT1). Validated for Flow, IF and IHC.
Alias Names WT1, GUD, EWS-WT1, Amino-terminal domain of EWS, WAGR, WIT-2, Wilms tumor protein, AWT1, Wilms tumor 1, WT33, NPHS4
Protocol The applications listed have been tested for the unmodified form of this product. Other forms have not been tested. Recognizes a 47-55kDa-tumor suppressor protein, identified as Wilm's Tumor (WT1) protein. The antibody reacts with all isoforms of the full-length WT1 and also identifies WT1 lacking exon 2-encoded amino acids, frequently found in subsets of sporadic Wilm s tumors. WT1, a sporadic and familial pediatric kidney tumor, is genetically heterogeneous. Wilm s tumor is associated with mutations of WT1, a zinc-finger transcription factor that is essential for the development of the metanephric kidney and the urogenital system. The WT1 gene is normally expressed in fetal kidney and mesothelium, and its expression has been suggested as a marker for Wilm s tumor and mesothelioma. WT1 protein has been identified in proliferative mesothelial cells, malignant mesothelioma, ovarian carcinoma, gonadoblastoma, nephroblastoma, and desmoplastic small round cell tumor. Lung adenocarcinomas rarely stain positive with this antibody. WT1 protein expression in mesothelial cells has become a reliable marker for the diagnosis of mesotheliomas.
Purification Protein G purified
Size 7 ml
Source / Host mouse
Species Reactivity human
Storage Store at 2°C to 8°C.
Substrate / Buffer Protein G purified
Technical Specifications Human WT1 / Wilms Tumor 1
Product Page Updated 2019-04-25T06:30:31.345Z

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