Article No
LS-C389626-100
KRT8 / CK8 / Cytokeratin 8
Cytokeratin 8 antibody LS-C389626 is an unconjugated mouse monoclonal antibody to human Cytokeratin 8 (KRT8 / CK8). Validated for ELISA, Flow, IF, IHC, IP and WB.
Antibodies Primary
Specifications
| NCBI Number | 3856 |
| Application | ELISA, FC, IF, IHC, IP, WB |
| Article No | LS-C389626-100 |
| Country Availability | SE, FI, DK, NO, FO, GL |
| Clone | TS1 |
| Clone Type | monoclonal |
| Concentration | 1 mg/ml |
| Conjugation | Unconjugated |
| Description | Cytokeratin 8 antibody LS-C389626 is an unconjugated mouse monoclonal antibody to human Cytokeratin 8 (KRT8 / CK8). Validated for ELISA, Flow, IF, IHC, IP and WB. |
| Recommended Dilution | FC (0.5 - 1 ug/10e6 cells), IF (1 - 2 ug/ml), IHC-P (0.5 - 1 ug/ml) |
| Supplier | LifeSpan Biosciences |
| Entrez Gene ID | 3856 |
| Gene Symbol | KRT8 |
| Immunogen | Keratin preparation from a human carcinoma. |
| Isotype | IgG1 |
| Notes | Cytokeratin 8 antibody LS-C389626 is an unconjugated mouse monoclonal antibody to human Cytokeratin 8 (KRT8 / CK8). Validated for ELISA, Flow, IF, IHC, IP and WB. |
| Alias Names | KRT8, CARD2, CK-8, CYK8, Cytokeratin-8, CK8, K2C8, K8, KO, Keratin-8, Type-II keratin Kb8, Cytokeratin 8, Keratin 8 |
| Product Type | Antibodies Primary |
| Protocol | The applications listed have been tested for the unmodified form of this product. Other forms have not been tested. Cytokeratin 8 is the product of the KRT8 gene and one of the most abundant keratins. The KRT8 gene is a member of the type II keratin family clustered on the long arm of chromosome 12. Cytokeratin 8 participates in cellular differentiation and signal transduction, protects against apoptosis, stress and injury, and helps maintain cellular structural integrity. It is primarily found in the non-squamous epithelia and is present in majority of adenocarcinomas and ductal carcinomas. It is absent in squamous cell carcinomas. Specific combinations of cytokeratins are associated with certain epithelial cells, and therefore useful in the characterization of poorly differentiated carcinoma. Hepatocellular carcinomas are defined by the use of antibody that recognizes only cytokeratin 8 and 18. Keratin 8 exists on several types of normal and neoplastic epithelia, including many ductal and glandular epithelia such as colon, stomach, small intestine, trachea, and esophagus as well as in transitional epithelium. Antibody to Cytokeratin 8 does not react with skeletal muscle or nerve cells. Epithelioid sarcoma, chordoma, and adamantinoma show strong positivity corresponding to that of simple epithelia (with antibodies against Keratin 8, 18 and 19). Reportedly, Cytokeratin 8 antibody is useful for the differentiation of lobular (ring-like, perinuclear) from ductal (peripheral-predominant) carcinoma of the breast. ELISA: Order BSA-free format for coating. |
| Purification | Protein G Purified |
| Shipping Information | RT |
| Size | 100 µg |
| Source / Host | mouse |
| Species Reactivity | human |
| Storage | 4°C |
| Substrate / Buffer | Sterile Solution PBS |
| Technical Specifications | Human KRT8 / CK8 / Cytokeratin 8 |
| Product Page Updated | 2024-04-12T09:20:06.597Z |
