Article No
LS-C34594-250
NCBI Number | 975 |
Application | FC |
Article No | LS-C34594-250 |
Country Availability | SE, FI, DK, NO, FO, GL |
Clone | Eat2 |
Clone Type | monoclonal |
Conjugation | Unconjugated |
Description | CD81 antibody LS-C34594 is an unconjugated hamster monoclonal antibody to mouse CD81. Validated for Flow. |
Supplier | LifeSpan Biosciences |
Entrez Gene ID | 975 |
Gene Symbol | CD81 |
Isotype | IgG1 |
Notes | CD81 antibody LS-C34594 is an unconjugated hamster monoclonal antibody to mouse CD81. Validated for Flow. |
Alias Names | CD81, CD81 antigen, CD81 molecule, CVID6, S5.7, TAPA1, TAPA-1, Tetraspanin-28, TSPAN28, Tspan-28 |
Product Type | Antibodies Primary |
Protocol | Flo |
Purification | Protein G Purified |
Shipping Information | RT |
Size | 250 µg |
Source / Host | hamster |
Species Reactivity | mouse |
Storage | -20°C, 4°C |
Substrate / Buffer | PBS, 0.02% Sodium Azide |
Technical Specifications | Reacts with the extracellular loops of murine CD81 (TAPA-1) molecule. As a member of the tetraspanin superfamily of cell-surface proteins, CD81 has been linked to the control of cell proliferation, adhesion and motility. CD81 is expressed in higher levels on resting murine B cells than on resting T cells and is functionally active on B cells as it induces homotypic adhesion of B lymphocytes. Unlike human CD81, which is expressed equally on all thymocytes, murine CD81 is upregulated on CD4+CD8+ thymocytes, then down-regulated again on mature single-positive thymocytes. Murine dendritic cells, splenic macrophages and non-killer cells all express very high levels of CD81. CD81 has also been involved in the induction of IL-4 secretion from T cells during Th2 immune responses. It has been reported that CD81 expression can also be induced in mature T cells upon activation. This anti-CD81 mAb has been shown to decrease the proliferation of LPS stimulated CD81+/+ B cells to levels similar to that of CD81-/- B cells. |
Product Page Updated | 2024-03-11T11:55:05.043Z |