Article No
LS-C188628-0.5
LPL / Lipoprotein Lipase
Lipoprotein Lipase antibody LS-C188628 is an unconjugated mouse monoclonal antibody to bovine Lipoprotein Lipase (LPL). Validated for ELISA, IP and WB.
Antibodies Primary
Specifications
| NCBI Number | 4023 |
| Application | ELISA, IP, WB |
| Article No | LS-C188628-0.5 |
| Country Availability | SE, FI, DK, NO, FO, GL |
| Clone | 5D2 |
| Clone Type | monoclonal |
| Concentration | 1 mg/ml |
| Conjugation | Unconjugated |
| Description | Lipoprotein Lipase antibody LS-C188628 is an unconjugated mouse monoclonal antibody to bovine Lipoprotein Lipase (LPL). Validated for ELISA, IP and WB. |
| Recommended Dilution | ELISA (1:500 - 1:5000) |
| Supplier | LifeSpan Biosciences |
| Entrez Gene ID | 4023 |
| Gene Symbol | LPL |
| Immunogen | Purified bovine milk lipoprotein lipase. |
| Isotype | IgG1 |
| Notes | Lipoprotein Lipase antibody LS-C188628 is an unconjugated mouse monoclonal antibody to bovine Lipoprotein Lipase (LPL). Validated for ELISA, IP and WB. |
| Alias Names | LPL, LIPD, Lipoprotein lipase, HDLCQ11 |
| Product Type | Antibodies Primary |
| Protocol | The applications listed have been tested for the unmodified form of this product. Other forms have not been tested. |
| Purification | Protein G Purified |
| Shipping Information | RT |
| Size | 0.5 mg |
| Source / Host | mouse |
| Species Reactivity | cow/bovine |
| Storage | -20°C |
| Substrate / Buffer | PBS |
| Technical Specifications | Recognizes an epitope within amino acids 380-410 of lipoprotein lipase (LPL), a member of the AB hydrolase superfamily, which plays a pivotal role in lipoprotein metabolism and transport, acting as the key enzyme in the hydrolysis of triglycerides and very low density lipoproteins (VLDLs), and the release of free fatty acids into peripheral tissues. A deficiency of LPL can result in hypertriglyceridemia, and many studies have focused on the critical role which LPL plays in the pathogenesis of atherosclerosis, and in particular the relationship between LPL and apolipoprotein E (ApoE), both of which are secreted in significant amounts by macrophages in developing arterial wall lesions. Clone 5D2 is a unique antibody which differentiates between monomeric inactive and dimeric active LPL, and binds to LPL sequences involved in LPL, LPL receptor, and heparin interactions. Clone 5D2 has been shown to inhibit the activity of human LPL(2,3), and is widely used in human studies. |
| Product Page Updated | 2024-04-12T06:35:05.844Z |
