Article No
LS-C188623-0.5
APOE / Apolipoprotein E
Apolipoprotein E antibody LS-C188623 is an unconjugated mouse monoclonal antibody to human Apolipoprotein E (APOE). Validated for ELISA and WB.
Antibodies Primary
Specifications
| NCBI Number | 348 |
| Application | ELISA, WB |
| Article No | LS-C188623-0.5 |
| Country Availability | SE, FI, DK, NO, FO, GL |
| Clone | WUE-4 |
| Clone Type | monoclonal |
| Concentration | 1 mg/ml |
| Conjugation | Unconjugated |
| Description | Apolipoprotein E antibody LS-C188623 is an unconjugated mouse monoclonal antibody to human Apolipoprotein E (APOE). Validated for ELISA and WB. |
| Recommended Dilution | ELISA (1:100 - 1:1000) |
| Supplier | LifeSpan Biosciences |
| Entrez Gene ID | 348 |
| Gene Symbol | APOE |
| Immunogen | Purified ApoHDL fraction. |
| Isotype | IgG1 |
| Notes | Apolipoprotein E antibody LS-C188623 is an unconjugated mouse monoclonal antibody to human Apolipoprotein E (APOE). Validated for ELISA and WB. |
| Alias Names | APOE, AD2, Apo-E, Apolipoprotein E3, Apolipoprotein E, LDLCQ5, LPG |
| Product Type | Antibodies Primary |
| Protocol | The applications listed have been tested for the unmodified form of this product. Other forms have not been tested. |
| Purification | Protein G Purified |
| Shipping Information | RT |
| Size | 0.5 mg |
| Source / Host | mouse |
| Species Reactivity | human |
| Storage | -20°C |
| Substrate / Buffer | PBS |
| Technical Specifications | Recognizes an epitope within amino acids 140-160 of human apolipoprotein E (Apo-E), a major component of very low-density lipoproteins (VLDLs). Apo-E is the principle apolipoprotein in the central nervous system, and is secreted by most organs into the plasma, playing a vital role in the binding, internalization and catabolism of triglyceride-rich lipoprotein constituents. Apo-E acts as a ligand for both the specific apo-E receptor (chylomicron remnant) of hepatic tissues, and the apoB, E (LDL) receptor. Three isoforms of Apo-E have been identified, ApoE2, E3 and E4, and have been linked with various disorders. ApoE2 has been shown to bind LPL receptors with low affinity, resulting in increased plasma cholesterol and triglyceride levels, and thereby an increased risk in cardiovascular disorders. ApoE4 is a known high risk factor for Alzheimer's disease, and in particular late onset Alzheimer disease 2 (AD2), whilst ApoE3 is the most common isoform, and considered the normal/natural Apo-E genotype. Clone 6-4 has been shown to inhibit Apo-E mediated binding of lipoproteins to the apoB, E cell receptor. |
| Product Page Updated | 2024-04-12T06:35:05.844Z |
