8-OHdG Check ELISA Kit

Article No JAI-KOG-200SE
Product Type Assay & Detection
Research Area Inflammation
Application ELISA
Size 1 Kit

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Specifications

Country Availability DK, EE, FI, IS, LT, LV, NO, SE
Data Sheet Link https://www.adipogen.com/productmanagement/resource/download/type/sheet/id/5036
Description 8-OHdG Check ELISA Kit
Supplier Adipogen Life Sciences
Notes Kit. Specific for 8-OHdG. Has been tested to 8-OHdG analogues (guanosine(G),7-methyl-G, 6-SH-G, 8-Bromo-G, dA, dC, dT, dI, dU, dG, O6-methyl-dG,8-OHdA, guanine(Gua),O6-methyl-Gua, 8-OH-Gua, uric acid, urea, creatine, creatinine, 8-sulfhydryl-G, 8-OH-G). Range: 0.5 to 200 ng/mL. 8-hydroxy-2'-deoxyguanosine (8-OHdG) is a modified base that occurs in DNA due to attack by hydroxyl radicals (incl. singlet oxygen and direct photodynamic action) that are formed as byproducts and intermediates of aerobic metabolism and during oxidative stress. There is increasing evidence to support the involvement of free radical reactions in the damage of biomolecules that eventually lead to several diseases in humans, such as atherosclerosis, cerebral and heart ischemia-reperfusion injury, cancer, rheumatoid arthritis, inflammation, diabetes, aging, and neurodegenerative conditions, such as Alzheimer's disease. 8-OHdG is popular as a sensitive, stable and integral marker of oxidative damage in cellular DNA and can be detected in tissue, serum, urine and other biomaterials. This ELISA Kit is suitable for urine and serum samples from animal and human.
Alias Names 8-hydroxy-2' -deoxyguanosine
Protocol This ELISA Kit is suitable for urine and serum samples from animal and human. However, for human serum, tissue and cultured cells, we recommend 8-OHdG Check ELISA Kit (High Sensitivity) (JAI-KOG-HS10E). Detection Guide for Serum/Plasma http://www.jaica.com/e/8ohdg_serum.html Detection Guide for Urine http://www.jaica.com/e/8ohdg_urine.html
Range 0.5 to 200 ng/mL
References Quantitative determination of urinary 8-hydroxydeoxyguanosine (8-OH-dg) by using ELISA: S. Saito, et al.; Res. Commun. Mol. Pathol. Pharmacol. 107, 39 (2000) [Development and assessment of 8-OHdG Check ELISA] | Urinary 8-hydroxy-2'-deoxyguanosine levels increase after reperfusion in acute myocardial infarction and may predict subsequent cardiac events: Y. Nagayoshi, et al.; Am. J. Cardiol. 95, 514 (2005) [Measurement of 8-OHdG in human urine] | The effects of an antioxidant-supplemented beverage on exercise-induced oxidative stress: results from a placebo-controlled double-blind study in cyclists: J. Morillas-Ruiz, et al.; Eur. J. Appl. Physiol. 95, 543 (2005) [Study about exercise, antioxidant supplements and urinary 8-OHdG] | Effect of a novel free radical scavenger, edaravone, on puromycin aminonucleoside induced nephrosis in rats: T. Someya, et al.; Pediatr. Nephrol. 20, 1430 (2005) [Effect of antioxidants to 8-OHdG in rat urine] | Acute encephalopathy with refractory status epilepticus: Bilateral mesial temporal and claustral lesions, associated with a peripheral marker of oxidative DNA damage: T. Shiihara, et al.; J. Neurol. Sci. 250, 159 (2006) [Measurement of 8-OHdG in human urine, serum and cerebro spinal fluid(CSF)] | Click here for more literature references! http://www.jaica.com/e/technical_forum_8ohdg.html#8OHDG_KIT_REF
Sample Type Urine
Species Reactivity species independent
Storage +4°C
Technical Specifications 8-hydroxy-2'-deoxyguanosine (8-OHdG) is a modified base that occurs in DNA due to attack by hydroxyl radicals (incl. singlet oxygen and direct photodynamic action) that are formed as byproducts and intermediates of aerobic metabolism and during oxidative stress. There is increasing evidence to support the involvement of free radical reactions in the damage of biomolecules that eventually lead to several diseases in humans, such as atherosclerosis, cerebral and heart ischemia-reperfusion injury, cancer, rheumatoid arthritis, inflammation, diabetes, aging, and neurodegenerative conditions, such as Alzheimer’s disease. 8-OHdG is popular as a sensitive, stable and integral marker of oxidative damage in cellular DNA and can be detected in tissue, serum, urine and other biomaterials.

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Species reactivity:

species independent

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Product data sheet

Datasheet