Article No
GTX84990
Specifications
| Application | ELISA, WB |
| Article No | GTX84990 |
| Country Availability | SE, FI, DK, NO, IS, EE, LV, LT |
| Clone | 10C5G1 |
| Clone Type | monoclonal |
| Concentration | 1 mg/ml |
| Conjugation | Unconjugated |
| Control Tissue | K562 Cell Lysate(GTX27911) , PUMA Recombinant Protein(GTX48024-PRO) |
| Description | PUMA antibody [10C5G1] |
| Supplier | GeneTex |
| Entrez Gene ID | 27113 |
| Gene Symbol | BBC3 |
| Immunogen | Recombinant protein corresponding to amino acids 76 - 170 of human PUMA-alpha. |
| Isotype | IgG1 |
| Notes | Apoptosis is related to many diseases and development. The p53 tumor-suppressor protein induces apoptosis through transcriptional activation of several genes. A novel p53 inducible pro-apoptotic gene was identified recently and designated PUMA (for p53 upregulated modulator of apoptosis) and bbc3 (for Bcl-2 binding component 3) in human and mouse. PUMA/bbc3 is one of the pro-apoptotic Bcl-2 family members including Bax and Noxa, which are also transcriptional targets of p53. The PUMA gene encodes two BH3 domain-containing proteins termed PUMA-a and PUMA-b. PUMA proteins bind Bcl-2, localize to the mitochondria, and induce cytochrome c release and apoptosis in response to p53. PUMA may be a direct mediator of p53-induced apoptosis. |
| Product Type | Antibodies Primary |
| Protocol | WB: 2.5 to 5 µg/mL. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications. |
| Purification | Affinity Purified |
| Size | 100µg |
| Source / Host | mouse |
| Species Reactivity | human, rat |
| Storage | 4°C, -80°C |
| UniProt Number | Q96PG8, Q9BXH1 |
| Product Page Updated | 2024-01-03T10:31:47.950Z |
