Article No
GTX84485
Specifications
| Application | FC, ICC, IF, IHC, WB |
| Article No | GTX84485 |
| Country Availability | SE, FI, DK, NO, IS, EE, LV, LT |
| Clone | 3C10 |
| Clone Type | monoclonal |
| Concentration | 1 mg/ml |
| Conjugation | Unconjugated |
| Description | FOXA2 antibody [3C10] |
| Supplier | GeneTex |
| Entrez Gene ID | 3170 |
| Gene Symbol | FOXA2 |
| Immunogen | Recombinant protein expressed in E.coli corresponding to amino acids 300-458 of human FOXA2 |
| Isotype | IgG1 |
| Notes | Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity). In embryonic development is required for notochord formation. Involved in the development of multiple endoderm-derived organ systems such as the liver, pancreas and lungs | FOXA1 and FOXA2 seem to have at least in part redundant roles. Originally discribed as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis | regulates the expression of genes important for glucose sensing in pancreatic beta-cells and glucose homeostasis. Involved in regulation of fat metabolism. Binds to fibrinogen beta promoter and is involved in IL6-induced fibrinogen beta transcriptional activation. |
| Product Type | Antibodies Primary |
| Protocol | WB: 1:1000. ICC/IF: 1:50-1:100. IHC-P: 1:50. FACS: 1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications. |
| Purification | Affinity Purified |
| Size | 100µl |
| Source / Host | mouse |
| Species Reactivity | human, mouse |
| Storage | 4°C, -80°C |
| UniProt Number | Q9Y261 |
| Product Page Updated | 2024-01-03T10:31:47.950Z |
