Article No
GTX84319
Specifications
| Application | ICC, IF, WB |
| Article No | GTX84319 |
| Country Availability | SE, FI, DK, NO, IS, EE, LV, LT |
| Clone | 2H9 |
| Clone Type | monoclonal |
| Concentration | 1 mg/ml |
| Conjugation | Unconjugated |
| Description | IDH1 antibody [2H9] |
| Supplier | GeneTex |
| Entrez Gene ID | 3417 |
| Gene Symbol | IDH1 |
| Immunogen | Full-length protein expressed in 293T cell transfected with human IDH1 expression vector |
| Isotype | IgG1 |
| Notes | Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the cytoplasm and peroxisomes. It contains the PTS-1 peroxisomal targeting signal sequence. The presence of this enzyme in peroxisomes suggests roles in the regeneration of NADPH for intraperoxisomal reductions, such as the conversion of 2, 4-dienoyl-CoAs to 3-enoyl-CoAs, as well as in peroxisomal reactions that consume 2-oxoglutarate, namely the alpha-hydroxylation of phytanic acid. The cytoplasmic enzyme serves a significant role in cytoplasmic NADPH production. [provided by RefSeq] |
| Product Type | Antibodies Primary |
| Protocol | WB: 1:2000. ICC/IF: 1:100. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications. |
| Purification | Affinity Purified |
| Size | 100µl |
| Source / Host | mouse |
| Species Reactivity | human |
| Storage | 4°C, -80°C |
| UniProt Number | O75874 |
| Product Page Updated | 2024-01-03T10:31:47.950Z |
