Article No
GTX80198
CD28
The CD28.2 antibody reacts with human CD28, a 44 kDa type I surface glycoprotein which acts as a co-stimulatory receptor in support of the T cell receptor (TCR). CD28 exists as a homodimer with specificity for two known ligands, known as B7-1 (CD80) and B7-2 (CD86), which are expressed on activated B cells and antigen-presenting cells. These ligands trigger CD28 signaling in concert with TCR activation to drive T cell proliferation, induce high-level expression of IL-2, impart resistance to apoptosis, and enhance T cell cytotoxicity. The interaction / co-stimulatory signaling between the B7 ligands and CD28 provides crucial communication between T cells and B cells or APCs to coordinate the adaptive immune response. Other members of the CD28 family of receptors include CTLA-4 (CD152), PD-1 (CD279), ICOS and BTLA.
Antibodies Primary
Specifications
| Application | FC |
| Article No | GTX80198 |
| Country Availability | SE, FI, DK, NO, IS, EE, LV, LT |
| Clone | CD28.2 |
| Clone Type | monoclonal |
| Concentration | 0.05 mg/ml |
| Conjugation | APC |
| Description | The CD28.2 antibody reacts with human CD28, a 44 kDa type I surface glycoprotein which acts as a co-stimulatory receptor in support of the T cell receptor (TCR). CD28 exists as a homodimer with specificity for two known ligands, known as B7-1 (CD80) and B7-2 (CD86), which are expressed on activated B cells and antigen-presenting cells. These ligands trigger CD28 signaling in concert with TCR activation to drive T cell proliferation, induce high-level expression of IL-2, impart resistance to apoptosis, and enhance T cell cytotoxicity. The interaction / co-stimulatory signaling between the B7 ligands and CD28 provides crucial communication between T cells and B cells or APCs to coordinate the adaptive immune response. Other members of the CD28 family of receptors include CTLA-4 (CD152), PD-1 (CD279), ICOS and BTLA. |
| Supplier | GeneTex |
| Entrez Gene ID | 940 |
| Gene Symbol | CD28 |
| Immunogen | DC28.1.3.3 murine T cell hybridoma transfected with human CD28 cDNA |
| Isotype | IgG1 |
| Notes | The protein encoded by this gene is essential for T-cell proliferation and survival, cytokine production, and T-helper type-2 development. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2011] |
| Product Type | Antibodies Primary |
| Protocol | FACS: 0.25 µg (5 µl) for 10⁵-10⁸ cells in 100 µl sample per test. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications. |
| Purification | Affinity Purified |
| Size | 100test |
| Source / Host | mouse |
| Species Reactivity | human, mammals, monkey |
| Storage | 4°C |
| UniProt Number | P10747 |
| Product Page Updated | 2024-01-03T10:31:47.950Z |
