Article No
GTX48644
PDCD4 (phospho Ser457)
PDCD4 (phospho Ser457) antibody [2E10.C12]
Antibodies Primary
Specifications
| Application | ELISA, IHC, WB |
| Article No | GTX48644 |
| Country Availability | SE, FI, DK, NO, IS, EE, LV, LT |
| Clone | 2E10.C12 |
| Clone Type | monoclonal |
| Concentration | 1 mg/ml |
| Conjugation | Unconjugated |
| Description | PDCD4 (phospho Ser457) antibody [2E10.C12] |
| Supplier | GeneTex |
| Entrez Gene ID | 27250 |
| Gene Symbol | PDCD4 |
| Immunogen | Anti-Pdcd4 phospho S457 Antibody was produced by repeated immunizations with a synthetic peptide corresponding to residues surrounding Ser457 of the human Pdcd4 protein. |
| Isotype | IgG1 |
| Notes | Programmed cell death 4 (Pdcd4) is a novel tumor supressor. Pdcd4 directly inhibits the helicase activity of eukaryotic translation initiation factor 4A (eIF4A), a component of the translation initiation complex. Pdcd4 also suppresses the transactivation of activator protein-1 (AP-1)-responsive promoters by c-Jun. Pdcd4 contains two Akt phosphoryl-ation sites, one at Ser67 and the other at Ser457. The phosphorylation of Pdcd4 by Akt causes nuclear translocation of Pdcd4 and a significant decrease in the ability of Pdcd4 to interfere with the transactivation of AP-1-responsive promoters by c-Jun. |
| Product Type | Antibodies Primary |
| Protocol | WB: 1:1000 - 1:3000. ELISA: 1:400000. IHC: 1.25 - 2.5 µg/mL. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications. |
| Purification | Protein A Purified |
| Size | 100µg |
| Source / Host | mouse |
| Species Reactivity | frog, human, mouse, rat |
| Storage | 4°C, -80°C |
| UniProt Number | Q53EL6 |
| Product Page Updated | 2024-01-03T10:31:47.950Z |
