Article No
GTX38935
Application | ELISA, FC, ICC, IF, IHC, IP, WB |
Article No | GTX38935 |
Country Availability | SE, FI, DK, NO, IS, EE, LV, LT |
Clone | TS106 |
Clone Type | monoclonal |
Concentration | 1 mg/ml |
Conjugation | Unconjugated |
Description | Thymidylate synthase antibody [TS106] |
Supplier | GeneTex |
Entrez Gene ID | 7298 |
Gene Symbol | TYMS |
Immunogen | Recombinant Thymidylate synthase. |
Isotype | IgG1 |
Notes | Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using, 10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occurring antisense transcript, mitochondrial enolase superfamily member 1 (GeneID:55556), vary inversely when cell-growth progresses from late-log to plateau phase. Polymorphisms in this gene may be associated with etiology of neoplasia, including breast cancer, and response to chemotherapy. [provided by RefSeq, Aug 2017] |
Product Type | Antibodies Primary |
Protocol | WB: 1/200-1/400. IHC-P: 1/50-1/100. IHC-Fr: 1/50-1/100. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications. |
Purification | Purified |
Size | 100µg |
Source / Host | mouse |
Species Reactivity | human |
Storage | 4°C, -80°C |
UniProt Number | P04818 |
Product Page Updated | 2024-01-03T10:31:47.950Z |