Article No
GTX33911
ADAM17
ADAM17 antibody [D1(A12)] (Azide free)
Antibodies Primary
Specifications
| Application | Inhibition, Neutralization |
| Article No | GTX33911 |
| Country Availability | SE, FI, DK, NO, IS, EE, LV, LT |
| Clone | D1(A12) |
| Clone Type | monoclonal |
| Concentration | 1 mg/ml |
| Conjugation | Unconjugated |
| Description | ADAM17 antibody [D1(A12)] (Azide free) |
| Supplier | GeneTex |
| Entrez Gene ID | 6868 |
| Gene Symbol | ADAM17 |
| Immunogen | Recombinant human ADAM17 (TACE) ectodomain tagged to biotin. |
| Isotype | IgG1 |
| Notes | This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The encoded preproprotein is proteolytically processed to generate the mature protease. The encoded protease functions in the ectodomain shedding of tumor necrosis factor-alpha, in which soluble tumor necrosis factor-alpha is released from the membrane-bound precursor. This protease also functions in the processing of numerous other substrates, including cell adhesion proteins, cytokine and growth factor receptors and epidermal growth factor (EGF) receptor ligands. The encoded protein also plays a prominent role in the activation of the Notch signaling pathway. Elevated expression of this gene has been observed in specific cell types derived from psoriasis, rheumatoid arthritis, multiple sclerosis and Crohn's disease patients, suggesting that the encoded protein may play a role in autoimmune disease. [provided by RefSeq, Feb 2016] |
| Product Type | Antibodies Primary |
| Protocol | Neutralizing/Inhibition: . *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications. |
| Purification | Protein A/G Purified |
| Size | 100µg |
| Source / Host | human |
| Species Reactivity | human |
| Storage | 4°C, -80°C |
| UniProt Number | P78536 |
| Product Page Updated | 2024-01-03T10:31:47.950Z |
