Article No
GTX21276
Application | ELISA, ICC, IF, IHC, IP, PLA, WB |
Article No | GTX21276 |
Country Availability | SE, FI, DK, NO, IS, EE, LV, LT |
Clone Type | polyclonal |
Concentration | 1 mg/ml |
Conjugation | Unconjugated |
Description | SMC1 (phospho Ser966) antibody |
Supplier | GeneTex |
Entrez Gene ID | 8243 |
Gene Symbol | SMC1A |
Immunogen | Immunogen for this antibody was a phosphorylated synthetic peptide, which represented a portion of human Structural Maintenance of Chromosomes 1 (GeneID 8243) around serine 966 according to the numbering given in entry NP_006297.2. |
Isotype | IgG |
Notes | Proper cohesion of sister chromatids is a prerequisite for the correct segregation of chromosomes during cell division. The cohesin multiprotein complex is required for sister chromatid cohesion. This complex is composed partly of two structural maintenance of chromosomes (SMC) proteins, SMC3 and either SMC1L2 or the protein encoded by this gene. Most of the cohesin complexes dissociate from the chromosomes before mitosis, although those complexes at the kinetochore remain. Therefore, the encoded protein is thought to be an important part of functional kinetochores. In addition, this protein interacts with BRCA1 and is phosphorylated by ATM, indicating a potential role for this protein in DNA repair. This gene, which belongs to the SMC gene family, is located in an area of the X-chromosome that escapes X inactivation. [provided by RefSeq] |
Product Type | Antibodies Primary |
Protocol | WB: 1:500 - 1:5000. ICC/IF: 1:250 - 1:1000. IHC-P: 1:500 - 1:2000. IP: 2 - 6 µg/mg lysate. ELISA: 1:100 - 1:2000. PLA: 1:1000 - 1:20000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications. |
Purification | Affinity Purified |
Size | 50µg |
Source / Host | rabbit |
Species Reactivity | human, mouse |
Storage | 4°C |
UniProt Number | Q14683 |
Product Page Updated | 2024-01-03T10:31:47.950Z |