Article No
GTX14056
Application | WB |
Article No | GTX14056 |
Country Availability | SE, FI, DK, NO, IS, EE, LV, LT |
Clone Type | polyclonal |
Conjugation | Unconjugated |
Description | LDL receptor antibody |
Supplier | GeneTex |
Entrez Gene ID | 3949 |
Gene Symbol | LDLR |
Immunogen | Immunogen Sequence: GI # 4504975, sequence 29-205 Recombinant low density lipoprotein receptor |
Isotype | IgY |
Notes | The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. |
Product Type | Antibodies Primary |
Protocol | WB: 1:500. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications. |
Purification | Affinity Purified |
Size | 50µg |
Source / Host | chicken |
Species Reactivity | human, mouse, rat |
Storage | 4°C, -80°C |
UniProt Number | P01130 |
Product Page Updated | 2024-01-03T10:31:47.950Z |