Article No
GTX13990
Application | WB |
Article No | GTX13990 |
Country Availability | SE, FI, DK, NO, IS, EE, LV, LT |
Clone Type | polyclonal |
Conjugation | Unconjugated |
Description | AKT antibody |
Supplier | GeneTex |
Entrez Gene ID | 207 |
Gene Symbol | AKT1 |
Immunogen | Immunogen Sequence: GI # 62241011, sequence 2-200 Recombinant serine/threonine protein kinase |
Isotype | IgY |
Notes | AKT (Protein Kinase B, PKB) was originally cloned from the retrovirus AKT8, and is a key regulator of many signal transduction pathways. Its tight control over cell proliferation and cell viability are manifold; overexpression or inappropriate activation of Akt has been seen in many types of cancer. AKT mediates many of the downstream events of phosphatidylinositol 3 kinase (a lipid kinase activated by growth factors, cytokines and insulin). PI 3 kinase recruits AKT to the membrane, where it is activated by PDK1 phosphorylation. Once phosphorylated, AKT dissociates from the membrane and phosphorylates targets in the cytoplasm and the cell nucleus. AKT has two main roles: (i) inhibition of apoptosis; (ii) promotion of proliferation. |
Product Type | Antibodies Primary |
Protocol | WB: 1:500. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications. |
Purification | Affinity Purified |
Size | 50µg |
Source / Host | chicken |
Species Reactivity | human, mouse, rat |
Storage | 4°C, -80°C |
UniProt Number | P31749 |
Product Page Updated | 2024-01-03T10:31:47.950Z |