Article No
GTX12338
Specifications
| Application | IHC, WB |
| Article No | GTX12338 |
| Country Availability | SE, FI, DK, NO, IS, EE, LV, LT |
| Clone Type | monoclonal |
| Concentration | 1 mg/ml |
| Conjugation | Unconjugated |
| Description | APP antibody [3E9] |
| Supplier | GeneTex |
| Entrez Gene ID | 351 |
| Gene Symbol | APP |
| Immunogen | Synthetic peptide: LEVPTDGNAGLLAEPQIAMFC , corresponding to amino acids 18-38 of Human Amyloid Precursor Protein. |
| Isotype | IgG1 |
| Notes | This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. In addition, two of the peptides are antimicrobial peptides, having been shown to have bacteriocidal and antifungal activities. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Aug 2014] |
| Product Type | Antibodies Primary |
| Protocol | IHC-P: Use at a concentration of 5 - 10 µg/ml. WB: Use at a concentration of 5 - 10 µg/ml. Predicted molecular weight: 87 kDa. Optimal dilutions/concentrations should be determined by the end user. |
| Purification | Protein A Purified |
| Size | 50µg |
| Source / Host | mouse |
| Species Reactivity | human, mouse |
| Storage | 4°C, -80°C |
| UniProt Number | P05067 |
| Product Page Updated | 2024-01-03T10:31:47.950Z |
