Article No
GTX01856
Mouse Anti-Human IgM antibody
Mouse Anti-Human IgM antibody [8H6]
Antibodies Secondary
Specifications
| Application | IHC |
| Article No | GTX01856 |
| Country Availability | SE, FI, DK, NO, IS, EE, LV, LT |
| Clone | 8H6 |
| Clone Type | monoclonal |
| Concentration | > 41 ug/ml |
| Conjugation | Unconjugated |
| Description | Mouse Anti-Human IgM antibody [8H6] |
| Supplier | GeneTex |
| Entrez Gene ID | 3507 |
| Gene Symbol | IGHM |
| Immunogen | Prokaryotic recombinant protein corresponding to a portion of the N terminus of the heavy chain constant region. |
| Isotype | IgG2a |
| Notes | Immunoglobulins (Ig) are the antigen recognition molecules of B cells. An Ig molecule is made up of 2 identical heavy chains and 2 identical light chains (see MIM 147200) joined by disulfide bonds so that each heavy chain is linked to a light chain and the 2 heavy chains are linked together. Each Ig heavy chain has an N-terminal variable (V) region containing the antigen-binding site and a C-terminal constant (C) region, encoded by an individual C region gene, that determines the isotype of the antibody and provides effector or signaling functions. The heavy chain V region is encoded by 1 each of 3 types of genes: V genes (see MIM 147070), joining (J) genes (see MIM 147010), and diversity (D) genes (see MIM 146910). The C region genes are clustered downstream of the V region genes within the heavy chain locus on chromosome 14. The IGHM gene encodes the C region of the mu heavy chain, which defines the IgM isotype. Naive B cells express the transmembrane forms of IgM and IgD (see IGHD; MIM 1471770) on their surface. During an antibody response, activated B cells can switch to the expression of individual downstream heavy chain C region genes by a process of somatic recombination known as isotype switching. In addition, secreted Ig forms that act as antibodies can be produced by alternative RNA processing of the heavy chain C region sequences. Although the membrane forms of all Ig isotypes are monomeric, secreted IgM forms pentamers, and occasionally hexamers, in plasma (summary by Janeway et al., 2005).[supplied by OMIM, Aug 2010] |
| Product Type | Antibodies Secondary |
| Protocol | IHC-P: 1:800. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications. |
| Purification | Unpurified |
| Size | 500µl |
| Source / Host | mouse |
| Species Reactivity | human |
| Storage | 4°C |
| Product Page Updated | 2024-01-03T10:31:47.950Z |
