Article No
D032-3
Anti-Proton Pump (H,K-ATPase beta subunit) (Mouse) mAb
Anti-Proton Pump (H,K-ATPase beta subunit) (Mouse) mAb
Antibodies Primary
Specifications
| Application | IHC, IP, WB |
| Article No | D032-3 |
| Country Availability | SE, FI, DK, NO, IS, EE, LV, LT, FO, GL |
| Clone | 2B6 |
| Clone Type | monoclonal |
| Concentration | 1 mg/ml |
| Conjugation | Unconjugated |
| Description | Anti-Proton Pump (H,K-ATPase beta subunit) (Mouse) mAb |
| Supplier | MBL |
| Immunogen | Hybridoma, fusion of spleen cells Balb / c nu removal of thymus cells and induce Sp2/0-Ag14 myeloma, autoimmune gastritis / + mouse neonatal |
| Isotype | IgG1 |
| Notes | Hydrogen-potassium adenosine triphosphatase (H + , K + -ATPase) belongs to a family of P-type cation-transporting ATPases that also includes Ca 2+ -ATPase and Na + , K + -ATPase. H + , K + -ATPase is responsible for acid secre tion into the stomach and catalyzes electroneutral excha nge of cytoplasmic hydrogen ions and external potassium ions coupled with ATP hydrolysis. The enzyme is found in gastric parietal cells where it is located in cytoplasmi c vesicles or apical plasma membranes of the secretory canaliculus. H + , K + -ATPase is a heterodimer consisting of a high molecular weight catalytic α subunit and a smaller but heavily glycosylated α subunit. The α subunit of H + , K + -ATPase has 10 transmembrane domains and contains sites for ATP binding and its acylphosphorylation, binding sites of proton pump inhibitors, and sites responsible for ion recognition. |
| Product Type | Antibodies Primary |
| Research area | Cell Death |
| Shipping Information | 4°C |
| Size | 100 µg |
| Source / Host | mouse |
| Species Reactivity | human, mouse, rat, cow/bovine |
| Stability | 1 year |
| Storage | -20°C |
| Substrate / Buffer | 100µg IgG in 100µl volume of PBS containing 50% glycerol, pH 7.2. No preservative is contained. |
| Technical Specifications | Hydrogen-potassium adenosine triphosphatase (H + , K + -ATPase) belongs to a family of P-type cation-transporting ATPases that also includes Ca 2+ -ATPase and Na + , K + -ATPase. H + , K + -ATPase is responsible for acid secre tion into the stomach and catalyzes electroneutral excha nge of cytoplasmic hydrogen ions and external potassium ions coupled with ATP hydrolysis. The enzyme is found in gastric parietal cells where it is located in cytoplasmi c vesicles or apical plasma membranes of the secretory canaliculus. H + , K + -ATPase is a heterodimer consisting of a high molecular weight catalytic α subunit and a smaller but heavily glycosylated α subunit. The α subunit of H + , K + -ATPase has 10 transmembrane domains and contains sites for ATP binding and its acylphosphorylation, binding sites of proton pump inhibitors, and sites responsible for ion recognition. |
| Product Page Updated | 2023-12-29T16:20:16.638Z |
