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|MW||Recombinant human 14-3-3 Tau demonstrates approximately 54 kDa band by SDS-PAGE analysis.|
|Country Availability||DK, EE, FI, FO, GL, IS, LT, LV, NO, SE|
|Data Sheet Link||https://www.mblintl.com/assets/cy-r2146.pdf|
|Description||14-3-3 τ (Human)|
|Supplier||MBL International Corp.|
|Notes||14-3-3 protein family is highly conserved from plants to mammals and ubiquitously expressed cellular proteins. In mammals, there are seven isoforms encoded by a distinct gene (Beta, Epsilon, Gamma, Sigma, Eta, Tau and Zeta). More than 200 target proteins of the 14-3-3 protein family have been identified. Interactions of 14-3-3 proteins and the target proteins are dependent on phosphorylation of serine/threonine residue on the target proteins with some exceptions. 14-3-3 is deeply and widely involved in mitogenic signaling, cell cycle regulation and cell death/survival, suggesting the family plays important role in human neoplastic and neurological diseases.|
|Alias Names||The gene accession number is NM_006826.|
|References||1. Mackintosh C. Dynamic interactions between 14-3-3 proteins and phosphoproteins regulate diverse cellular processes. Biochem J. 2004 Jul 15;381(Pt 2):329-42. 2. Dougherty MK, Morrison DK. Unlocking the code of 14-3-3. J Cell Sci. 2004 Apr 15;117(Pt 10):1875-84. 3. Hermeking H. The 14-3-3 cancer connection. Nat Rev Cancer. 2003 Dec;3(12):931-43. 4. Berg D, Holzmann C, Riess O. 14-3-3 proteins in the nervous system. Nat Rev Neurosci. 2003 Sep;4(9):752-62.|
|Substrate / Buffer||Recombinant human 14-3-3 Tau is supplied frozen in phosphate buffered saline (PBS) containing 50 % glycerol.|
|Product Page Updated||2019-01-15T09:09:13.918Z|
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