Recombinant human 14-3-3 Eta demonstrates approximately 54 kDa band by SDS-PAGE analysis.
14-3-3 η (Human)
MBL International Corp.
14-3-3 protein family is highly conserved from plants to mammals and ubiquitously expressed cellular proteins. In mammals, there are seven isoforms encoded by a distinct gene (Beta, Epsilon, Gamma, Sigma, Eta, Tau and Zeta). More than 200 target proteins of the 14-3-3 protein family have been identified. Interactions of 14-3-3 proteins and the target proteins are dependent on phosphorylation of serine/threonine residue on the target proteins with some exceptions. 14-3-3 is deeply and widely involved in mitogenic signaling, cell cycle regulation and cell death/survival, suggesting the family plays important role in human neoplastic and neurological diseases.
The gene accession number is L20422.
Proteins & Peptides
1. Mackintosh C. Dynamic interactions between 14-3-3 proteins and phosphoproteins regulate diverse cellular processes. Biochem J. 2004 Jul 15;381(Pt 2):329-42.
2. Dougherty MK, Morrison DK. Unlocking the code of 14-3-3. J Cell Sci. 2004 Apr 15;117(Pt 10):1875-84.
3. Hermeking H. The 14-3-3 cancer connection. Nat Rev Cancer. 2003 Dec;3(12):931-43.
4. Berg D, Holzmann C, Riess O. 14-3-3 proteins in the nervous system. Nat Rev Neurosci. 2003 Sep;4(9):752-62.
Substrate / Buffer
Recombinant human 14-3-3 Eta is supplied frozen in phosphate buffered saline (PBS) containing 50 % glycerol.
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