Article No
CSB-PA356939LD01HMN-100
Specifications
| Application | ELISA |
| Article No | CSB-PA356939LD01HMN-100 |
| Country Availability | SE, FI, DK, NO, IS, EE, LV, LT, FO, GL |
| Clone Type | polyclonal |
| Conjugation | Biotin |
| Description | L2 Antibody, Biotin conjugated |
| Supplier | Cusabio |
| Entrez Gene ID | 1489091 |
| Gene Symbol | L2 |
| Immunogen | Recombinant Human papillomavirus type 18 Minor capsid protein L2 protein (1-462AA) |
| Isotype | IgG |
| Notes | Minor protein of the capsid that localizes along the inner surface of the virion, within the central cavities beneath the L1 pentamers. Plays a role in capsid stabilization through interaction with the major capsid protein L1. Once the virion enters the host cell, escorts the genomic DNA into the nucleus, in particular by promoting virion endosomal escape. It is involved, through its interaction with host dynein, in the intracellular microtubule-dependent transport of viral capsid toward the nucleus. Mediates the viral genome import into the nucleus through binding to host importins. Mediates the viral genome import into the nucleus through binding to host importins. Once within the nucleus, L2 localizes viral genomes to PML bodies in order to activate early gene expression for establishment of infection. Later on, promotes late gene expression by interacting with the viral E2 protein and by inhibiting its transcriptional activation functions. During virion assembly, encapsidates the genome by direct interaction with the viral DNA (By similarity). |
| Product Type | Antibodies Primary |
| Purification | Protein G Purified |
| Shipping Information | BLUE ICE |
| Size | 100ug |
| Source / Host | rabbit |
| Species Reactivity | virus |
| Storage | -80°C |
| UniProt Number | P06793 |
| Product Page Updated | 2024-01-24T13:11:22.259Z |
