Article No
CSB-PA14209C0Rb-100
Application | ELISA, IF |
Article No | CSB-PA14209C0Rb-100 |
Country Availability | SE, FI, DK, NO, IS, EE, LV, LT, FO, GL |
Clone Type | polyclonal |
Conjugation | FITC |
Description | AGER Antibody, FITC conjugated |
Supplier | Cusabio |
Entrez Gene ID | 177 |
Gene Symbol | AGER |
Immunogen | Recombinant Human Advanced glycosylation end product-specific receptor protein (23-342AA) |
Isotype | IgG |
Notes | Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling By similarity. Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space. |
Product Type | Antibodies Primary |
Purification | Protein G Purified |
Shipping Information | BLUE ICE |
Size | 100ug |
Source / Host | rabbit |
Species Reactivity | human |
Storage | -80°C |
UniProt Number | Q15109 |
Product Page Updated | 2024-01-24T13:11:22.259Z |