Article No
CSB-PA007460LC01RA-100
Application | ELISA, IF |
Article No | CSB-PA007460LC01RA-100 |
Country Availability | SE, FI, DK, NO, IS, EE, LV, LT, FO, GL |
Clone Type | polyclonal |
Conjugation | FITC |
Description | Efna1 Antibody, FITC conjugated |
Supplier | Cusabio |
Entrez Gene ID | 94268 |
Gene Symbol | Efna1 |
Immunogen | Recombinant Rat Ephrin-A1 protein (18-182AA) |
Isotype | IgG |
Notes | Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. Exerts anti-oncogenic effects in tumor cells through activation and down-regulation of EPHA2. Activates EPHA2 by inducing tyrosine phosphorylation which leads to its internalization and degradation. Acts as a negative regulator in the tumorigenesis of gliomas by down-regulating EPHA2 and FAK. Can evoke collapse of embryonic neuronal growth cone and regulates dendritic spine morphogenesis By similarity. |
Product Type | Antibodies Primary |
Purification | Protein G Purified |
Shipping Information | BLUE ICE |
Size | 100ug |
Source / Host | rabbit |
Species Reactivity | rat |
Storage | -80°C |
UniProt Number | P97553 |
Product Page Updated | 2024-01-24T13:11:22.259Z |