Article No
CSB-PA001502HC01HU-100
Specifications
| Application | ELISA, IF |
| Article No | CSB-PA001502HC01HU-100 |
| Country Availability | SE, FI, DK, NO, IS, EE, LV, LT, FO, GL |
| Clone Type | polyclonal |
| Conjugation | FITC |
| Description | AIRE Antibody, FITC conjugated |
| Supplier | Cusabio |
| Entrez Gene ID | 326 |
| Gene Symbol | AIRE |
| Immunogen | Recombinant Human Autoimmune regulator protein (39-108AA) |
| Isotype | IgG |
| Notes | Transcriptional regulator that binds to DNA as a dimer or as a tetramer, but not as a monomer. Binds to G-doublets in an A/T-rich environment; the preferred motif is a tandem repeat of 5\'-. ATTGGTTA-3\' combined with a 5\'-TTATTA-3\' box. Binds to nucleosomes (By similarity). Binds to chromatin and interacts selectively with histone H3 that is not methylated at \'Lys-4\', not phosphorylated at \'Thr-3\' and not methylated at \'Arg-2\'. Functions as a sensor of histone H3 modifications that are important for the epigenetic regulation of gene expression. Functions as a transcriptional activator and promotes the expression of otherwise tissue-specific self-antigens in the thymus, which is important for self tolerance and the avoidance of autoimmune reactions. |
| Product Type | Antibodies Primary |
| Purification | Protein G Purified |
| Shipping Information | BLUE ICE |
| Size | 100ug |
| Source / Host | rabbit |
| Species Reactivity | human |
| Storage | -80°C |
| UniProt Number | O43918 |
| Product Page Updated | 2024-01-24T13:11:22.259Z |
