Article No
CHI-HF-211B7H4-C100
MW | ~80kDa (monomer) |
Accession Number | NP_078902.2 |
Article No | CHI-HF-211B7H4-C100 |
Country Availability | SE, FI, DK, NO, IS, EE, LV, LT |
Description | B7-H4 (human):Fc (mouse) (rec.) |
Supplier | Adipogen Life Sciences |
Endotoxin | <1EU/mg protein (LAL test; Lonza). |
Format | Powder |
Notes | B7-H4 is a B7 family member that negatively regulates T cell immunity by inhibiting of T cell proliferation, cytokine production and cell cycle progression. In vitro, B7-H4 inhibits CD4+ and CD8+ T cell proliferation, cytokine production and generation of alloreactive cytotoxic T cells (CTLs). In vivo, blockade of endogenous B7-H4 by specific monoclonal antibody promotes T cell responses. B7-H4 ia an important negative regulator of innate immunity through growth inhibition of neutrophils. B7-H4 is expressed on some tumor cancer cells. The role of B7-H4 in tumor progression may be to transform precancerous cells and then protect them from immunosurveillance.|Protein. The extracellular domain of human B7-H4 (aa 29-258) is fused to the N-terminus of the Fc region of mouse IgG2a. Source: CHO cells. Endotoxin content: 98% (SDS-PAGE). B7-H4 is a B7 family member that negatively regulates T cell immunity by inhibiting of T cell proliferation, cytokine production and cell cycle progression. In vitro, B7-H4 inhibits CD4+ and CD8+ T cell proliferation, cytokine production and generation of alloreactive cytotoxic T cells (CTLs). In vivo, blockade of endogenous B7-H4 by specific monoclonal antibody promotes T cell responses. B7-H4 ia an important negative regulator of innate immunity through growth inhibition of neutrophils. B7-H4 is expressed on some tumor cancer cells. The role of B7-H4 in tumor progression may be to transform precancerous cells and then protect them from immunosurveillance. |
Alias Names | V-set Domain-containing T Cell Activation Inhibitor 1; VTCN1; B7h.5; Immune Costimulatory Protein B7-H4; T Cell Costimulatory Molecule B7x; Protein B7S1 |
Product Type | Proteins & Peptides |
Purity | >95% |
Research Area | Immunology |
Sequence | The extracellular domain of human B7-H4 (aa 29-258) is fused to the N-terminus of the Fc region of mouse IgG2a. |
Shipping Information | BLUE ICE |
Size | 100 ug |
Source / Host | human |
Stability | Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C. |
Storage | -20°C, 4°C |
Substrate / Buffer | Lyophilized from 0.2µm-filtered solution in PBS. |
Technical Specifications | Protein. The extracellular domain of human B7-H4 (aa 29-258) is fused to the N-terminus of the Fc region of mouse IgG2a. Source: CHO cells. Endotoxin content: 98% (SDS-PAGE). B7-H4 is a B7 family member that negatively regulates T cell immunity by inhibiting of T cell proliferation, cytokine production and cell cycle progression. In vitro, B7-H4 inhibits CD4+ and CD8+ T cell proliferation, cytokine production and generation of alloreactive cytotoxic T cells (CTLs). In vivo, blockade of endogenous B7-H4 by specific monoclonal antibody promotes T cell responses. B7-H4 ia an important negative regulator of innate immunity through growth inhibition of neutrophils. B7-H4 is expressed on some tumor cancer cells. The role of B7-H4 in tumor progression may be to transform precancerous cells and then protect them from immunosurveillance. |
UniProt Number | NP_078902.2 |
Product Page Updated | 2024-02-01T08:25:01.492Z |