Anti-AIDS agents. 32. Synthesis and anti-HIV activity of betulin derivatives: I.-C. Sun, et al.; Bioorg. Med. Chem. Lett. 8, 1267 (1998) | Anti-AIDS agents. 34. Synthesis and structure-activity relationships of betulin derivatives as anti-HIV agents: I.-C. Sun, et al.; J. Med. Chem. 41, 4648 (1998) | 3,28-Di-O-(dimethylsuccinyl)-betulin isomers as anti-HIV agents: Y. Kashiwada, et al.; Bioorg. Med. Chem. Lett. 11, 183 (2001) | 3-O-Glutaryl-dihydrobetulin and related monoacyl derivatives as potent anti-HIV agents: Y. Kashiwada, et al.; Bioorg. Med. Chem. Lett. 14, 5851 (2004) | Birch bark research and development: P.A. Krasutsky; Nat. Prod. Rep. 23, 919 (2006) | Pharmacological properties of the ubiquitous natural product betulin: S. Alakurtti, et al.; Eur. Pharm. Sci. 29, 1 (2006)
Soluble in methanol, acetone or DMSO.
Stable for at least 1 year after receipt when stored at -20°C. After reconstitution protect from light at -20°C.
Chemical. Formula: C44H70O8. MW: 727. Semi-synthetic derivative from betulin (from birch bark). Semi-synthetic derivative of betulin (from birch bark). Potent antiviral compound. Shows anti-HIV activity (more active than AZT in vitro).
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