Article No
BVT-0098-M001
CAS No | 7184-60-3 |
MW | 489.6 |
Article No | BVT-0098-M001 |
Country Availability | SE, FI, DK, NO, IS, EE, LV, LT |
Description | Borrelidin |
Supplier | Adipogen Life Sciences |
Format | Powder |
Notes | Chemical. CAS: 7184-60-3. Formula: C28H43NO6. MW: 489.6. Isolated from Streptomyces sp. Macrolide antibiotic. Bacterial, protozoan and mammalian threonyl-tRNA synthetase (THrRS) inhibitor. Antiangiogenic (IC50 = 0.8 nM) and anticancer agent. Induces the collapse of formed capillary tubes in a dose-dependent fashion. In HUVECs, the capillary tube collapsing activity is mediated by the activation of caspases-3 and -8 and induction of apoptosis. Blocks the formation of spontaneous lung metastases of B16-BL6 melanoma cells. Cyclin-dependent kinase (CDK) inhibitor. Antiviral. Potent antimalarial agent (IC50 = 0.97 nM). Inhibitor of potato scab disease.|Macrolide antibiotic. Bacterial, protozoan and mammalian threonyl-tRNA synthetase (THrRS) inhibitor. Antiangiogenic (IC50 = 0.8 nM) and anticancer agent. Induces the collapse of formed capillary tubes in a dose-dependent fashion. In HUVECs, the capillary tube collapsing activity is mediated by the activation of caspases-3 and -8 and induction of apoptosis. Blocks the formation of spontaneous lung metastases of B16-BL6 melanoma cells. Cyclin-dependent kinase (CDK) inhibitor. Antiviral. Potent antimalarial agent (IC50 = 0.97 nM). Inhibitor of potato scab disease. |
Molecular Formula | C28H43NO6 |
Alias Names | Treponemycin; U 78548; C2989 |
Product Type | Chemicals & Biochemicals |
Purity | >98% |
Research area | Cell Death |
Shipping Information | RT |
Size | 1 mg |
Solubility | Soluble in DMSO or methanol. |
Stability | Stable for at least 1 year after receipt when stored at -20°C. After reconstitution protect from light at -20°C. |
Storage | -20°C, 4°C |
Technical Specifications | Chemical. CAS: 7184-60-3. Formula: C28H43NO6. MW: 489.6. Isolated from Streptomyces sp. Macrolide antibiotic. Bacterial, protozoan and mammalian threonyl-tRNA synthetase (THrRS) inhibitor. Antiangiogenic (IC50 = 0.8 nM) and anticancer agent. Induces the collapse of formed capillary tubes in a dose-dependent fashion. In HUVECs, the capillary tube collapsing activity is mediated by the activation of caspases-3 and -8 and induction of apoptosis. Blocks the formation of spontaneous lung metastases of B16-BL6 melanoma cells. Cyclin-dependent kinase (CDK) inhibitor. Antiviral. Potent antimalarial agent (IC50 = 0.97 nM). Inhibitor of potato scab disease. |
Product Page Updated | 2024-02-01T08:25:01.492Z |