Article No
BT-IRHCT6-1
Chapare mammarenavirus Nucleocapsid Protein(CHAPV-NP)
Chapare mammarenavirus Nucleocapsid Protein(CHAPV-NP)
Proteins & Peptides
Specifications
| MW | 1686bp;47kDa |
| Article No | BT-IRHCT6-1 |
| Biosite Brand | Biosite |
| Country Availability | all |
| Description | Chapare mammarenavirus Nucleocapsid Protein(CHAPV-NP) |
| Supplier | Nordic Biosite |
| Notes | Encapsidates the genome, protecting it from nucleases. The encapsidated genomic RNA is termed the nucleocapsid (NC). Serves as template for viral transcription and replication. The increased presence of protein N in host cell does not seem to trigger the switch from transcription to replication as observed in other negative strain RNA viruses. Through the interaction with host IKBKE, strongly inhibits the phosphorylation and nuclear translocation of host IRF3, a protein involved in interferon activation pathway, leading to the inhibition of interferon-beta and IRF3-dependent promoters activation. Encodes also a functional 3'-5' exoribonuclease that degrades preferentially dsRNA substrates and thereby participates in the suppression of interferon induction. |
| Product Type | Proteins & Peptides |
| Protocol | Reseach |
| Purification | Transferred into competent cells and the supernatant was purified by NI column affinity chromatography and the purity is > 85% (by SDS-PAGE). |
| Purity | Transferred into competent cells and the supernatant was purified by NI column affinity chromatography and the purity is > 85% (by SDS-PAGE). |
| Size | 1mg |
| Source / Host | synthetic |
| Species Reactivity | bacteria |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. |
| Substrate / Buffer | Soluble protein;PBS,PH=7.4 |
| Swiss-Prot No | EU260463.1 |
| Product Page Updated | 2024-01-04T12:24:08.011Z |