Antibodies Primary

HER2

NEW
Anti-HER2, rabbit monoclonal - Optibodies

Article No

BSH-4004-100

Application

IHC

Species Reactivity

human

Size

100 µl

Clone

BSR44

Source / Host

rabbit

Suggested protocols

Specifications

Application IHC
Article No BSH-4004-100
BioSite Brand Optibodies
Clone BSR44
Clone Type monoclonal
Control Tissue HER2 negative and positive breast carcinoma cases
Description Anti-HER2, rabbit monoclonal - Optibodies
Supplier Nordic BioSite
Format Concentrate
Notes ERBB2: v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian). This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized
Alias Names HER-2/neu, ERBB2
Product Type Antibodies Primary
Protocol suitable for IHC-P
Size 100 µl
Source / Host rabbit
Species Reactivity human
Storage Store at 4℃
Substrate / Buffer TRIS with 0.03% sodium azide, pH7,2
Technical Specifications Control: HER2 negative and positive breast carcinoma cases
UniProt Number P04626
Product Page Updated 2019-06-11T14:48:29.489Z

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