Article No
BSH-4004-100
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Antibodies Primary
HER2
Anti-HER2, rabbit monoclonal - Optibodies
Product insert
Suggested protocols
Specifications
| Application | IHC |
| Article No | BSH-4004-100 |
| BioSite Brand | Optibodies |
| Clone | BSR44 |
| Clone Type | monoclonal |
| Control Tissue | HER2 negative and positive breast carcinoma cases |
| Description | Anti-HER2, rabbit monoclonal - Optibodies |
| Supplier | Nordic BioSite |
| Format | Concentrate |
| Notes | ERBB2: v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian). This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized |
| Alias Names | HER-2/neu, ERBB2 |
| Product Type | Antibodies Primary |
| Protocol | suitable for IHC-P |
| Size | 100 µl |
| Source / Host | rabbit |
| Species Reactivity | human |
| Storage | Store at 4℃ |
| Substrate / Buffer | TRIS with 0.03% sodium azide, pH7,2 |
| Technical Specifications | Control: HER2 negative and positive breast carcinoma cases |
| UniProt Number | P04626 |
| Product Page Updated | 2019-06-11T14:48:29.489Z |
Shipping info
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