HER2
Specifications
| Country Availability | all |
| BioSite Brand | Optibodies |
| Clone | BSR44 |
| Clone Type | monoclonal |
| Control Tissue | HER2 negative and positive breast carcinoma cases |
| Description | Anti-HER2, rabbit monoclonal - Optibodies |
| Supplier | Nordic BioSite |
| CE/IVD | true |
| Notes | ERBB2: v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian). This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized |
| Alias Names | HER-2/neu, ERBB2 |
| Protocol | suitable for IHC-P |
| Source / Host | rabbit |
| Species Reactivity | human |
| Storage | Store at 4℃ |
| Substrate / Buffer | TRIS with 0.03% sodium azide, pH7,2 |
| Technical Specifications | Control: HER2 negative and positive breast carcinoma cases |
| UniProt Number | P04626 |
| Product Page Updated | 2019-02-20T14:36:52.701Z |
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Shipping info
The delivery time for this item is approximately 5-8 business days. If other deviations occur, this will be noted on the order confirmation or communicated via email. Please note, we do reserve the right to select the best packaging and shipping method in order to insure the stability of the product and allow efficient order tracking.
