Article No
BPS-71656
Specifications
| Additional Information | Bace1 (β-secretase 1) is an aspartic protease that is involved in the processing of the Amyloid precursor protein (APP). Cleavage of APP by BACE1 followed by γ-secretase results in β-amyloid peptide production, which ultimately leads toxic Aβ accumulation. In Alzheimer's disease (AD), it has been widely accepted that Aβ aggregation plays a critical role in AD pathogenesis, suggesting that BACE1 could be a potential target to treat AD. The BACE1 FRET Assay Kit is designed to measure BACE1 activity for screening and profiling applications based on fluorescence resonance energy transfer (FRET) using a labeled peptide substrate (below). |
| Article No | BPS-71656 |
| Country Availability | SE, FI, DK, NO, IS, EE, LV, LT |
| Components | The BACE1 FRET Assay Kit comes in a convenient 96-well format, with enough purified recombinant human BACE1 enzyme, BACE1 FRET peptide substrate, and assay buffer for 100 enzyme reactions. |
| Description | BACE1 Assay Kit |
| Supplier | BPS Bioscience |
| Notes | Bace1 (β-secretase 1) is an aspartic protease that is involved in the processing of the Amyloid precursor protein (APP). Cleavage of APP by BACE1 followed by γ-secretase results in β-amyloid peptide production, which ultimately leads toxic Aβ accumulation. In Alzheimer's disease (AD), it has been widely accepted that Aβ aggregation plays a critical role in AD pathogenesis, suggesting that BACE1 could be a potential target to treat AD. The BACE1 FRET Assay Kit is designed to measure BACE1 activity for screening and profiling applications based on fluorescence resonance energy transfer (FRET) using a labeled peptide substrate (below). |
| Alias Names | beta-site amyloid precursor protein cleaving enzyme 1, ASP2 |
| Product Type | Assay & Detection |
| Protocol | See assay kit data sheet for detailed protocol. |
| Research area | Neuroscience |
| Shipping Information | -80°C (dry ice) |
| Size | 96 rxns. |
| Storage | At least 12 months from date of receipt, when stored as directed. Kit components require different storage conditions. Be sure to store each component at the proper temperature upon arrival. |
| Technical Specifications | Useful for studying enzyme kinetics and screening small molecular inhibitors for drug discovery and HTS applications. |
| Product Page Updated | 2024-01-09T13:23:45.900Z |
