Article No
BPS-40833
LRRK2 (G2385R), GST-Tag Recombinant
LRRK2 (G2385R), GST-Tag Recombinant
Proteins & Peptides
Specifications
| MW | 210 kDa |
| Accession Number | NM_198578 |
| Additional Information | LRRK2 or leucine-rich repeat kinase is a protein with an ankryin repeat region, a leucine-rich repeat (LRR) domain, a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, a MLK-like domain, and a WD40 domain. Mutations in LRRK2 are the most frequent known cause of autosomal dominant and idiopathic Parkinson's disease with prevalent mutations being found within the GTPase and kinase domains (1). LRRK2 cooperates with MET to promote efficient tumor cell growth and survival in various cancers. Down-regulation of LRRK2 in cultured tumor cells compromises MET activation and selectively reduces downstream MET signaling to mTOR and STAT3 (2). |
| Application | FA |
| Article No | BPS-40833 |
| Country Availability | SE, FI, DK, NO, IS, EE, LV, LT |
| Description | LRRK2 (G2385R), GST-Tag Recombinant |
| Supplier | BPS Bioscience |
| Format | Aqueous buffer solution |
| Notes | Human LRRK2 protein with a G2385R mutation, also known as PARK8, RIPK7, and ROCO2, GenBank Accession No. NM_198578, amino acids 968-end, with an N-terminal GST-tag, expressed in an SF9cell expression system. MW = 210 kDa. |
| Alias Names | PARK8; RIPK7; ROCO2; AURA17; DARDARIN |
| Product Type | Proteins & Peptides |
| Shipping Information | -80°C (dry ice) |
| Size | 10 µg |
| Source / Host | insect |
| Species Reactivity | human |
| Storage | Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |
| Substrate / Buffer | 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol. |
| Technical Specifications | Kinase Assay |
| UniProt Number | Q5S007 |
| Product Page Updated | 2024-01-09T13:23:45.900Z |
