1,10-Phenanthroline, Monohydrate

1,10-Phenanthroline, Monohydrate

Proteins & Peptides

Article No

BPS-27713

Size

0.5 ml

Shipping Information

room temp.

Article No

BPS-27713

Size

0.5 ml

Shipping Information

room temp.

Specifications

CAS No 5144-89-8
MW 198.2 Da
Additional Information 1,10-phenanthroline (o-phenanthroline) is a chelator with high affinity for divalent metal ions. When complexed with copper, it possesses nuclease activity that has been used to study DNA-protein interactions. While not specific for DUBs, it has been shown to be a potent inhibitor of JAMM-type isopeptidases through chelation of the active site Zn2+ ion. As such, o-phenanthroline is widely used when preparing cell lysates for enrichment of proteins bearing K63-linked polyubiquitin chains which are especially sensitive to DUBs in the JAMM family.
Article No BPS-27713
Country Availability SE, FI, DK, NO, IS, EE, LV, LT, RU
Description 1,10-Phenanthroline, Monohydrate
Supplier BPS Bioscience
Format DMSO solution
Notes 1,10-phenanthroline (o-phenanthroline) is a chelator with high affinity for divalent metal ions. When complexed with copper, it possesses nuclease activity that has been used to study DNA-protein interactions. While not specific for DUBs, it has been shown to be a potent inhibitor of JAMM-type isopeptidases through chelation of the active site Zn2+ ion. As such, o-phenanthroline is widely used when preparing cell lysates for enrichment of proteins bearing K63-linked polyubiquitin chains which are especially sensitive to DUBs in the JAMM family.
Molecular Formula C12H8N2 • H2O
Alias Names o-phenanthroline
Product Type Proteins & Peptides
Purity ≥99%
Shipping Information room temp.
Size 0.5 ml
Technical Specifications Useful for inhibition of JAMM-family isopeptidases. Especially valuable for protecting K63-linked polyubiquitin chains in cell lysates.
Product Page Updated 2022-11-23T12:47:04.099Z

References

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