Article No
BPS-27602-3
Specifications
| CAS No | 328543-09-5 |
| MW | 320.4 Da |
| Additional Information | A 17-hour exposure of A549 cells to 0.4 µM AG14361 does not change the expression of the 6800 genes. Thus, although 0.4 µM AG14361 inhibits cellular PARP-1 activity by more than 85%, it essentially does not change gene expression and cell proliferation, indicating that the cellular effects of this low concentration of AG14361 are specific for PARP-1 inhibition. Higher, growth-inhibitory concentrations of AG14361 affects gene expression, but these effects are not likely to be related to PARP-1 inhibition because cell proliferation is affected equally in PARP-/- and PARP-1+/+ cells. |
| Article No | BPS-27602-3 |
| Country Availability | SE, FI, DK, NO, IS, EE, LV, LT |
| Description | AG-14361 |
| Supplier | BPS Bioscience |
| Notes | AG14361 is a potent inhibitor of PARP1 with Ki of <5 nM. It is at least 1000-fold more potent than the benzamides. AG14361 treatment before irradiation statistically significantly increases the sensitivity to radiation therapy. AG14361 enhances the growth-inhibitory and cytotoxic effects of topoisomerase I poisons and increases the persistence of camptothecin-induced DNA single-strand breaks. |
| Molecular Formula | C19H20N4O |
| Alias Names | 1-(4-((dimethylamino)methyl)phenyl)-8,9-dihydro-2,7,9a-triazabenzo[cd]azulen-6(7H)-one |
| Product Type | Chemicals & Biochemicals |
| Purity | ≥98% by HPLC |
| Shipping Information | Room temp. (continental US) or gel packs |
| Size | 50 mg |
| Solubility | Soluble in DMSO. Solubility in water or ethanol is <1 mg/ml |
| Storage | Store at or below -20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day. |
| Technical Specifications | A 17-hour exposure of A549 cells to 0.4 µM AG14361 does not change the expression of the 6800 genes. Thus, although 0.4 µM AG14361 inhibits cellular PARP-1 activity by more than 85%, it essentially does not change gene expression and cell proliferation, indicating that the cellular effects of this low concentration of AG14361 are specific for PARP-1 inhibition. Higher, growth-inhibitory concentrations of AG14361 affects gene expression, but these effects are not likely to be related to PARP-1 inhibition because cell proliferation is affected equally in PARP-/- and PARP-1+/+ cells. |
| Product Page Updated | 2024-01-09T12:32:15.877Z |
