(+)-JQ1

Article No BPS-27402
Product Type Chemicals & Biochemicals
Size 5 mg

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Specifications

CAS No 1268524-70-4
MW 457.0 Da
Additional Information (+)-JQ1 is a specific inhibitor of the BET family of acetyl-lysine recognition motifs, including the BRD2, BRD3, BRD4 and BRDT bromodomains.
Country Availability SE, FI, DK, NO, IS, EE, LV, LT
Data Sheet Link http://bpsbioscience.com/media/wysiwyg/27402_Lot140627.pdf
Description (+)-JQ1 is a specific inhibitor of the BET family of acetyl-lysine recognition motifs, including the BRD2, BRD3, BRD4 and BRDT bromodomains.
Supplier BPS Bioscience Inc
Notes (+)-JQ1 has been shown to inhibit BRD4 (BD1) with a Kd of 50 nM, and BRD4 (BD2) with a Kd of 90 nM.
Alias Names BET inhibitor, Bromodomain inhibitor
Purity ≥95% by HPLC
References Filippakopoulos, P., et al., Nature. 468(7327):1067-73 (2011)._x000D_ _x000D_ Application Reference:_x000D_ <br>1. <a href="http://www.ncbi.nlm.nih.gov/pubmed/?term=25769527_x000D_ "target="_blank">Deacetylase inhibitors repress STAT5-mediated transcription by interfering with bromodomain and extra-terminal (BET) protein function_x000D_ (2015)_x000D_ <br>2. <a href="http://www.ncbi.nlm.nih.gov/pubmed/24807963_x000D_ "target="_blank">BET bromodomain inhibitors block growth of pancreatic cancer cells in three-dimensional collagen_x000D_ (2014)_x000D_ <br>3. <a href="http://www.ncbi.nlm.nih.gov/pubmed/24584101_x000D_ "target="_blank">Dual kinase-bromodomain inhibitors for rationally designed polypharmacology_x000D_ (2014)_x000D_ <br>4. <a href="http://www.ncbi.nlm.nih.gov/pubmed/24231268 _x000D_ "target="_blank">BET bromodomain protein inhibition is a therapeutic option for medulloblastoma_x000D_ (2013)
Solubility Soluble in DMSO or ethanol; insoluble in water.
Storage Store at or below +4°C. Stable at least 6 months from date of receipt, when stored as directed.
Technical Specifications (+)-JQ1 is a specific inhibitor of the BET family of acetyl-lysine recognition motifs, including the BRD2, BRD3, BRD4 and BRDT bromodomains.
Product Page Updated 2019-01-04T10:01:58.434Z

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Datasheet