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|Additional Information||(+)-JQ1 is a specific inhibitor of the BET family of acetyl-lysine recognition motifs, including the BRD2, BRD3, BRD4 and BRDT bromodomains.|
|Country Availability||SE, FI, DK, NO, IS, EE, LV, LT|
|Data Sheet Link||http://bpsbioscience.com/media/wysiwyg/HDACs/27401_Lot140627.pdf|
|Description||(+)-JQ1 is a specific inhibitor of the BET family of acetyl-lysine recognition motifs, including the BRD2, BRD3, BRD4 and BRDT bromodomains.|
|Supplier||BPS Bioscience Inc|
|Notes||(+)-JQ1 has been shown to inhibit BRD4 (BD1) with a Kd of 50 nM, and BRD4 (BD2) with a Kd of 90 nM.|
|Alias Names||BET inhibitor, Bromodomain inhibitor|
|Purity||≥95% by HPLC|
|References||Filippakopoulos P., et al. Nature. 468(7327):1067-73 (2011)._x000D_ _x000D_ Application Reference(s):_x000D_ <br>1. <a href="http://www.ncbi.nlm.nih.gov/pubmed/?term=25769527_x000D_ "target="_blank">Deacetylase inhibitors repress STAT5-mediated transcription by interfering with bromodomain and extra-terminal (BET) protein function_x000D_ (2015)_x000D_ <br>2. <a href="http://www.ncbi.nlm.nih.gov/pubmed/24807963_x000D_ "target="_blank">BET bromodomain inhibitors block growth of pancreatic cancer cells in three-dimensional collagen_x000D_ (2014)_x000D_ <br>3. <a href="http://www.ncbi.nlm.nih.gov/pubmed/24584101_x000D_ "target="_blank">Dual kinase-bromodomain inhibitors for rationally designed polypharmacology_x000D_ (2014)_x000D_ <br>4. <a href="http://www.ncbi.nlm.nih.gov/pubmed/24231268 _x000D_ "target="_blank">BET bromodomain protein inhibition is a therapeutic option for medulloblastoma_x000D_ (2013)_x000D_|
|Solubility||Soluble in DMSO or ethanol; insoluble in water.|
|Storage||Store at or below +4°C. Stable at least 6 months from date of receipt, when stored as directed.|
|Technical Specifications||(+)-JQ1 is a specific inhibitor of the BET family of acetyl-lysine recognition motifs, including the BRD2, BRD3, BRD4 and BRDT bromodomains.|
|Product Page Updated||2019-01-04T10:01:58.434Z|
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