3-mC

Article No BPS-25200
Product Type Antibodies Primary
Research Area Epigenetics
Application Blotting
Size 50 µg

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Specifications

Additional Information Polyclonal antibody raised in rabbit against 3-methylcytosine (3-mC) conjugated to BSA.
Country Availability SE, FI, DK, NO, IS, EE, LV, LT
Clone Type polyclonal
Concentration 50 µg/28 µl
Data Sheet Link http://bpsbioscience.com/media/wysiwyg/Antibodies/25200_Lot150728.pdf
Description Anti-3-mC polyclonal antibody
Supplier BPS Bioscience Inc
Additional Information The optimal antibody concentration should be determined by the end-user.
Immunogen synthetic peptide
Notes Polyclonal antibody raised in rabbit against 3-methylcytosine (3-mC) conjugated to BSA.
Purification Protein G purified
Source / Host rabbit
Species Reactivity human, mouse, species independent
Storage Store at -80°C for up to 2 years. Centrifuge after first thaw to maximize product recovery. Aliquot to avoid repeated freeze/thaw cycles. Aliquots may be stored at -20°C for at least one month.
Substrate / Buffer PBS containing 0.05% azide and 0.05% ProClin 300.
Technical Specifications 3-methylcytosine arises by erroneous methylation of DNA through spontaneous exposure to endogenous S-adenosyl methionine (SAM). Since the N3-position in cytosine is protected in double stranded DNA, this phenomenon mainly occurs in single stranded DNA. The resulting 3-mC is toxic and mutagenic and increased levels of 3-mC seem to impair cell proliferation. Therefore, it has to be repaired by the cell. This is established by oxidative demethylation, which is catalyzed by the AlkB protein.

Shipping info

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Source/Host:

rabbit rabbit

Species reactivity:

human, mouse, species independent human mouse

Product insert:

Product data sheet

Datasheet