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|Additional Information||Polyclonal antibody raised in rabbit against 3-methylcytosine (3-mC) conjugated to BSA.|
|Country Availability||SE, FI, DK, NO, IS, EE, LV, LT|
|Concentration||50 µg/28 µl|
|Data Sheet Link||http://bpsbioscience.com/media/wysiwyg/Antibodies/25200_Lot150728.pdf|
|Description||Anti-3-mC polyclonal antibody|
|Supplier||BPS Bioscience Inc|
|Additional Information||The optimal antibody concentration should be determined by the end-user.|
|Notes||Polyclonal antibody raised in rabbit against 3-methylcytosine (3-mC) conjugated to BSA.|
|Purification||Protein G purified|
|Source / Host||rabbit|
|Species Reactivity||human, mouse, species independent|
|Storage||Store at -80°C for up to 2 years. Centrifuge after first thaw to maximize product recovery. Aliquot to avoid repeated freeze/thaw cycles. Aliquots may be stored at -20°C for at least one month.|
|Substrate / Buffer||PBS containing 0.05% azide and 0.05% ProClin 300.|
|Technical Specifications||3-methylcytosine arises by erroneous methylation of DNA through spontaneous exposure to endogenous S-adenosyl methionine (SAM). Since the N3-position in cytosine is protected in double stranded DNA, this phenomenon mainly occurs in single stranded DNA. The resulting 3-mC is toxic and mutagenic and increased levels of 3-mC seem to impair cell proliferation. Therefore, it has to be repaired by the cell. This is established by oxidative demethylation, which is catalyzed by the AlkB protein.|
The delivery time for this item is approximately 5-8 business days. If other deviations occur, this will be noted on the order confirmation or communicated via email. Please note, we do reserve the right to select the best packaging and shipping method in order to insure the stability of the product and allow efficient order tracking.